5 results for "Checkpoint Kinase Inhibitors Small Molecules and Peptides" in Products
Checkpoint Kinase Inhibitors: Small Molecules and Peptides
Checkpoint kinases (Chks) are serine/threonine kinases that are involved in the control of the cell cycle. Two subtypes have so far been identified, Chk1 and Chk2. They are essential components to delay cell cycle progression in normal and damaged cells and can act at all three cell cycle checkpoints.
Chks are activated by phosphorylation. ATR kinase phosphorylates Chk1 in response to single strand DNA breaks and ATM kinase phosphorylates Chk2 in response to double strand breaks. Chks ...
Potent and selective Wee1 inhibitor
| Alternate Names: | AZD 1775,MK 1775 |
| Chemical Name: | 1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one |
| Purity: | ≥98% (HPLC) |
Chk1 inhibitor
| Chemical Name: | 9,10,11,12-Tetrahydro- 9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione |
| Purity: | ≥98% (HPLC) |
Potent and selective inhibitor of Chk1 and Wee1
| Chemical Name: | 9-Hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione |
| Purity: | ≥98% (HPLC) |
Potent and selective Chk1 inhibitor
| Chemical Name: | N-[5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy)phenyl]-N'-(5-methyl-2-pyrazinyl)urea |
| Purity: | ≥98% (HPLC) |
Potent and selective Wee1 Degrader (PROTAC®)
| Chemical Name: | 4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione |
| Purity: | ≥98% (HPLC) |
