LY 2603618

Tocris Bioscience, part of Bio-Techne | Catalog # 6454

Potent and selective Chk1 inhibitor
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Key Product Details

Description

Potent and selective Chk1 inhibitor

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Product Description

LY 2603618 is a potent and selective Chk1 inhibitor (IC50 = 7 nM). Inhibits Chk1 autophosphorylation. Induces cell cycle arrest in the G2/M phase and induces the DNA damage response in lung cancer cells. Inhibits growth of NSCLC xenografts in mice when administered in combination with Pemetrexed (Cat.No. 6185).

Product Specifications

Molecular Weight

436.30

Formula

C18H22BrN5O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy)phenyl]-N'-(5-methyl-2-pyrazinyl)urea

CAS Number

911222-45-2

PubChem ID

11955855

InChI Key

SYYBDNPGDKKJDU-ZDUSSCGKSA-N

SMILES

CC1=CN=C(C=N1)NC(NC2=C(C=C(C(Br)=C2)C)OC[C@@H]3CNCCO3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.73 20

Preparing Stock Solutions for LY 2603618

The following data is based on the product molecular weight 436.30

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.46 mL 57.30 mL 114.60 mL
1 mM 2.29 mL 11.46 mL 22.92 mL
2 mM 1.15 mL 5.73 mL 11.46 mL
10 mM 0.23 mL 1.15 mL 2.29 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for LY 2603618

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LY 2603618

For research use only

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