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5 results for "CCL2/JE/MCP-1" in Products
CCL2/JE/MCP-1 Products
CCL2/JE/MCP-1, is a chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. It induces the activation of monocytes, NK cells, lymphocytes, and basophils. Additionally, CCL2 promotes Th2 polarization in CD4+ T cells, and CCL2-mediated recruitment of monocytes to sites of inflammation contributes to disease severity in atherosclerosis, multiple sclerosis, and allergic asthma. Endogenous proteolytic trimming of CCL2 at the N-terminus, including the N-terminal pyrrolidone carboxylic acid-modified glutamine, downregulates activity but not receptor binding.
Reactivity:
Human
Source:
E. coli
Accession #:
P13500.1
Applications:
Bioactivity
Reactivity:
Mouse
Source:
E. coli
Accession #:
Q5SVU3
Applications:
Bioactivity
Reactivity:
Rat
Source:
NS0
Accession #:
P14844
Applications:
Bioactivity
Reactivity:
Canine
Source:
E. coli
Accession #:
P52203
Applications:
Bioactivity
Reactivity:
Human
Source:
NS0
Accession #:
P13500 (CCL2) & P78423 (CX3CL1 Mucin-like Stalk)
Applications:
Bioactivity