BMP-2/BMP-7 Heterodimer: Proteins and Enzymes

BMP-7, also known as osteogenic protein 1 (OP-1), and BMP-2 are TGF-beta superfamily cytokines that influence a variety of morphogenic processes, particularly during skeletal and renal development. BMP-2 and BMP-7 are co-expressed in some embryonic tissues and associate into a functional 38 kDa osteogenic dimer. In in vitro osteoblast differentiation assays and in vivo bone formation models, BMP-2/BMP-7 is significantly more potent than either homodimer.

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