Bad: Small Molecules and Peptides
The Bcl-2 family of proteins consists of both inhibitors and promoters of apoptosis. The relative ratios of pro- and anti-apoptotic Bcl-2 family proteins determine the sensitivity or resistance of cells to a variety of apoptotic signals. The pro-apoptoptic Bad (Bcl-2-antagonist of cell death) heterodimerizes strongly with Bcl-x, less strongly with Bcl-2, and not at all with Bax, Bcl-xS, Mcl-1, A1, or itself. When Bad dimerizes with Bcl-xL, Bax is displaced and its apoptosis-inducing ability is restored.
3 results for "Bad Small Molecules and Peptides" in Products
3 results for "Bad Small Molecules and Peptides" in Products
Bad: Small Molecules and Peptides
The Bcl-2 family of proteins consists of both inhibitors and promoters of apoptosis. The relative ratios of pro- and anti-apoptotic Bcl-2 family proteins determine the sensitivity or resistance of cells to a variety of apoptotic signals. The pro-apoptoptic Bad (Bcl-2-antagonist of cell death) heterodimerizes strongly with Bcl-x, less strongly with Bcl-2, and not at all with Bax, Bcl-xS, Mcl-1, A1, or itself. When Bad dimerizes with Bcl-xL, Bax is displaced and its apoptosis-inducing ability is restored.
Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
| Alternate Names: | Triciribine,NSC 154020,TCN |
| Chemical Name: | 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine |
| Purity: | ≥98% (HPLC) |
Inhibitor of 14.3.3 proteins
| Purity: | ≥90% (HPLC) |
Cell-permeable protein kinase C inhibitor
| Chemical Name: | 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride |
| Purity: | ≥98% (HPLC) |
