R18

Name: R18
Brand: Tocris Bioscience
SKU: 2144

Tocris Bioscience, part of Bio-Techne | Catalog # 2144

Citations (10)

COA / SDS

Inhibitor of 14.3.3 proteins

Key Product Details

Description:	Inhibitor of 14.3.3 proteins
Purity:	≥90% (HPLC)
Molecular Weight:	2309.69

View Full Technical Details for R18

Technical Data
Citations

Biological Activity for R18

R18 is an antagonist of 14.3.3 proteins (K_D ≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S.

Technical Data for R18

M. Wt	2309.69
Formula	C₁₀₁H₁₅₇N₂₇O₂₉S₃
Single Letter Sequence	PHCVPRDLSWLDLEANMCLP
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	211364-78-2
PubChem ID	16138697
InChi Key	YSKZRNFKZLWXRG-ZHTKBQOPSA-N
Smiles	[H]N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for R18

Solubility

Soluble to 1mg/ml in water

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References for R18

References are publications that support the biological activity of the product.

Masters and Fu 14.3.3 proteins mediate an essential anti-apoptotic signal. J.Biol.Chem. 2001 PMID: 11577088
Masters Survival-promoting functions of 14.3.3 proteins. Biochem.Soc.Transactions
Wang Isolation of high-affinity peptide antagonists of 14.3.3 proteins by phage display. Biochemistry 1999 PMID: 10493820

R18

Tocris Bioscience, part of Bio-Techne | Catalog # 2144

Key Product Details

Biological Activity for R18

Technical Data for R18

Solubility for R18

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for R18

Product Documents for R18

COA

Certificate of Analysis

SDS

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