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4 results for "alpha-Synuclein Small Molecules and Peptides" in Products

alpha-Synuclein Small Molecules and Peptides

The synuclein family includes alpha-Synuclein, beta-Synuclein, gamma-Synuclein, and synoretin. These small, highly conserved proteins are localized predominantly in the brain, concentrated in presynaptic nerve terminals. Alpha-Synuclein is normally a soluble protein. Abnormal alpha-synuclein forms filamentous inclusions (Lewy bodies and Lewy neurites) in several neurodegenerative diseases, including Parkinson's disease (PD), dementia with Lewy bodies, and Alzheimer's disease. Beta-Synuclein and gamma-Synuclein (synoretin) associate with alpha-synuclein and inhibit its aggregation.

Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor

Alternate Names:
SM5,MALAT1-IN-1
Chemical Name:
5-(4-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-1H-Imidazol-2-amine
Purity:
≥98%
Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor

Potent COMT inhibitor; blocks α-synuclein aggregation

Chemical Name:
(2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
Purity:
≥98%
Potent COMT inhibitor; blocks α-synuclein aggregation

α-synuclein Degrader (PROTAC®)

Chemical Name:
2-[[3-[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-3-yl]phenyl]amino]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]acetamide
Purity:
≥98%
α-synuclein PROTAC® Degrader

Negative control for α Synuclein Degrader 2b (Cat. No. 8040)

Chemical Name:
2-[[3-[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-3-yl]phenyl]amino]-N-[2-[2-[2-[2-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]acetamide
Purity:
≥98%
Negative control for α Synuclein Degrader 2b (Cat. No. 8040)
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