TC SL C5

Name: TC SL C5
Brand: Tocris Bioscience
SKU: 6884

Tocris Bioscience, part of Bio-Techne | Catalog # 6884

COA / SDS

Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor

Key Product Details

Description:	Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor
Alternative Names:	SM5,MALAT1-IN-1
Chemical Name:	5-(4-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-1H-Imidazol-2-amine
Purity:	≥98% (HPLC)
Molecular Weight:	323.4

View Full Technical Details for TC SL C5

Technical Data
Citations

Biological Activity for TC SL C5

TC SL C5 is a metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor (K_D = 2.9 μM). Binds Malat1 3' terminal stability element for nuclear expression (ENE) triplex. Reduces Malat1 RNA levels by 54% and branching morphogenesis by 38% in mammary tumor organoids. Modulates Malat1 downstream genes without affecting Neat1.

Compound Libraries for TC SL C5

TC SL C5 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TC SL C5

M. Wt	323.4
Formula	C₁₉H₂₁N₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	827327-28-6
PubChem ID	1096509
InChi Key	LCVOJBGSGIOMKF-UHFFFAOYSA-N
Smiles	COC1=CC=C(C=C1)C1=CN=C(NCC2=CC(OC)=CC=C2)N1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC SL C5

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.34	100
	ethanol	32.34	100

Preparing Stock Solutions for TC SL C5

The following data is based on the product molecular weight 323.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.09 mL	15.46 mL	30.92 mL
5 mM	0.62 mL	3.09 mL	6.18 mL
10 mM	0.31 mL	1.55 mL	3.09 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for TC SL C5

References are publications that support the biological activity of the product.

Abulwerdi Selective small-molecule targeting of a triple helix encoded by the long noncoding RNA, MALAT1. ACS Chem.Biol. 2019 PMID: 30620551