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AIF-1/Iba1: Antibodies

Allograft-Inflammatory Factor 1 (AIF-1), also known as Ionized Calcium-Binding Adapter Molecule 1 (Iba1) and Diantain, is a macrophage/microglia-specific calcium-binding protein. Human AIF-1/Iba1 is 147 amino acids (aa) in length with a predicted molecule weight of approximately 17 kDa. This cytoplasmic protein contains two calcium-binding EF-hand motifs at aa 45-80 and 81-115. Alternative splicing produces a second isoform, which lacks the first 54 N-terminal aa, and a third isoform that lacks aa 1-54, as well as aa 121-147, but also has a 66 aa insertion at position 65. Human AIF-1/Iba1 shares 89% aa sequence identity with the mouse and rat orthologs.

AIF-1/Iba1 expression in macrophages and microglia is upregulated during the activation of these cells. It is important for the proinflammatory response to ischemia, tissue injury, and atherosclerosis. AIF-1/Iba1 is also expressed in vascular smooth muscle and endothelial cells, where it promotes vascular remodeling and new vessel formation. Additionally, AIF-1/Iba1 is upregulated in allografted tissue during transplant rejection and promotes the proliferation of breast cancer cells and in vivo tumorigenesis. 

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122 results for "AIF-1/Iba1 Primary Antibodies" in Products

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AIF-1/Iba1: Antibodies

Allograft-Inflammatory Factor 1 (AIF-1), also known as Ionized Calcium-Binding Adapter Molecule 1 (Iba1) and Diantain, is a macrophage/microglia-specific calcium-binding protein. Human AIF-1/Iba1 is 147 amino acids (aa) in length with a predicted molecule weight of approximately 17 kDa. This cytoplasmic protein contains two calcium-binding EF-hand motifs at aa 45-80 and 81-115. Alternative splicing produces a second isoform, which lacks the first 54 N-terminal aa, and a third isoform that lacks aa 1-54, as well as aa 121-147, but also has a 66 aa insertion at position 65. Human AIF-1/Iba1 shares 89% aa sequence identity with the mouse and rat orthologs.

AIF-1/Iba1 expression in macrophages and microglia is upregulated during the activation of these cells. It is important for the proinflammatory response to ischemia, tissue injury, and atherosclerosis. AIF-1/Iba1 is also expressed in vascular smooth muscle and endothelial cells, where it promotes vascular remodeling and new vessel formation. Additionally, AIF-1/Iba1 is upregulated in allografted tissue during transplant rejection and promotes the proliferation of breast cancer cells and in vivo tumorigenesis. 

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122 results for "AIF-1/Iba1 Primary Antibodies" in Products

Dual ISH-IHC, ELISA, ICC/IF, IHC, KO, WB
IHC, MA

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Flow, ICC/IF, IHC, Simple Western, WB
ELISA, Flow, ICC/IF, IHC
Flow, ICC/IF, IHC, IP, WB
ELISA, Flow, ICC/IF, IHC
ICC/IF, IHC, WB

Recombinant Monoclonal Antibody

ELISA, ICC/IF, IHC

Recombinant Monoclonal Antibody

ICC/IF, IHC, IP, WB

Recombinant Monoclonal Antibody

ICC/IF
ELISA, IP, WB

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

IHC, MA

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

IHC, MA

Recombinant Monoclonal Antibody

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