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Activin A: Antibodies

Activin A is an important member of the TGF-beta superfamily that is produced by many different cell types and is essential for proper development. Bioactive Activin A exists as a disulfide-linked homodimer that recognizes and binds to four Activin receptors, Activin RIA and RIB, and Activin RIIA and RIIB. This ligand-receptor binding event triggers activation of SMAD signaling pathways ultimately regulating a wide variety of functions including stem cell maintenance, self-renewal, and differentiation, B-cell differentiation and proliferation, wound healing, metabolism, and gonadal development.

Activin A is first produced as a precursor protein containing a propeptide that gets proteolytically cleaved off leaving the mature A chain. Two A chains assemble by disulfide bond formation creating the bioactive homodimer. The bioavailability of Activin A is regulated by cell-associated decoy molecules (BAMBI, Betaglycan, Cripto), secreted proteins (a2-Macroglobulin, Follistatin, FLRG), and intracellular incorporation of the beta A subunit into Activin AC or Inhibin A. Experimentally, recombinant Activin A is commonly used to maintain the proliferative potential of human induced pluripotent stem cells and to promote differentiation of embryonic stem cells into endoderm and pancreatic B cells.

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37 results for "Activin A Primary Antibodies" in Products

Activin A: Antibodies

Activin A is an important member of the TGF-beta superfamily that is produced by many different cell types and is essential for proper development. Bioactive Activin A exists as a disulfide-linked homodimer that recognizes and binds to four Activin receptors, Activin RIA and RIB, and Activin RIIA and RIIB. This ligand-receptor binding event triggers activation of SMAD signaling pathways ultimately regulating a wide variety of functions including stem cell maintenance, self-renewal, and differentiation, B-cell differentiation and proliferation, wound healing, metabolism, and gonadal development.

Activin A is first produced as a precursor protein containing a propeptide that gets proteolytically cleaved off leaving the mature A chain. Two A chains assemble by disulfide bond formation creating the bioactive homodimer. The bioavailability of Activin A is regulated by cell-associated decoy molecules (BAMBI, Betaglycan, Cripto), secreted proteins (a2-Macroglobulin, Follistatin, FLRG), and intracellular incorporation of the beta A subunit into Activin AC or Inhibin A. Experimentally, recombinant Activin A is commonly used to maintain the proliferative potential of human induced pluripotent stem cells and to promote differentiation of embryonic stem cells into endoderm and pancreatic B cells.

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37 results for "Activin A Primary Antibodies" in Products

WB, IHC, ICC, Neut
IHC, WB, ICC/IF
Catalog #: MAB1203
WB
Catalog #: BAF338
WB
ELISA, Flow, Func

Recombinant Monoclonal Antibody

ELISA

Recombinant Monoclonal Antibody

ELISA

Recombinant Monoclonal Antibody

ELISA

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

ELISA

Recombinant Monoclonal Antibody

ELISA

Recombinant Monoclonal Antibody

ELISA

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

ELISA

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

ELISA

Recombinant Monoclonal Antibody

ELISA

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

ELISA

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

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