10 results for "5-HT2B Small Molecules and Peptides" in Products
5-HT2B Small Molecules and Peptides
5-HT2B is one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G protein-coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors, including 5-HT2B, mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele which blocks expression of 5-HTRB, and knockout studies in mice, suggest a role for 5-HT2B in impulsivity.
D2-like agonist (D2>D3>D4)
Potent 5-HT2 antagonist; also 5-HT3, H1 and α2 antagonist; antidepressant
High affinity 5-HT2B antagonist; orally active
Potent and selective 5-HT2B and 5-HT2C antagonist; orally active
Potent 5-HT2 antagonist
High affinity and selective 5-HT2B antagonist
Endogenous 5-HT receptor agonist
Potent, selective 5-HT2B antagonist
Dopamine antagonist
Potent, selective 5-HT2B antagonist