SB 204741

Name: SB 204741
Brand: Tocris Bioscience
SKU: 1372

Tocris Bioscience, part of Bio-Techne | Catalog # 1372

Citations (48)

COA / SDS

Potent, selective 5-HT2B antagonist

Key Product Details

Description:	Potent, selective 5-HT_2B antagonist
Chemical Name:	N-(1-Methyl-1H-indolyl-5-yl)-N''-(3-methyl-5-isothiazolyl)urea
Purity:	≥98% (HPLC)
Molecular Weight:	286.35

View Full Technical Details for SB 204741

Technical Data
Citations

Biological Activity for SB 204741

SB 204741 is a potent and selective 5-HT_2B receptor antagonist (pA₂ = 7.95). Displays ≥ 135-fold selectivity over 5-HT_2C (pK_i = 5.82), 5-HT_2A (pK_i < 5.2), 5-HT_1A, _1D, _1E, 5-HT₃ and 5-HT₄ receptors.

Licensing Information

Sold under license

Compound Libraries for SB 204741

SB 204741 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SB 204741

M. Wt	286.35
Formula	C₁₄H₁₄N₄OS
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	152239-46-8
PubChem ID	3277600
InChi Key	USFUFHFQWXDVMH-UHFFFAOYSA-N
Smiles	O=C(NC3=CC(C)=NS3)NC1=CC(C=CN2C)=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 204741

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.64	100
	ethanol	5.73	20

Preparing Stock Solutions for SB 204741

The following data is based on the product molecular weight 286.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.49 mL	17.46 mL	34.92 mL
5 mM	0.70 mL	3.49 mL	6.98 mL
10 mM	0.35 mL	1.75 mL	3.49 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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References for SB 204741

References are publications that support the biological activity of the product.

Ebrahimkhani Stimulating healthy tissue regeneration by targeting the 5-HT_2B receptor in chronic liver disease. Nat.Med. 2011 PMID: 22120177
Forbes N-(1-Methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT_2B receptor antagonist. J.Med.Chem. 1995 PMID: 7699699
Glusa and Pertz Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT_2B receptors. Br.J.Pharmacol. 2000 PMID: 10821800
Bonhaus The pharmacology and distribution of human 5-hydroxytryptamine_2B (5-HT_2B) receptor gene products: comparison with 5-HT_2A and 5-HT_2C receptors. Br.J.Pharmacol. 1995 PMID: 7582481