SYM 2206

Tocris Bioscience, part of Bio-Techne | Catalog # 0961

Non-competitive AMPA antagonist
Discontinued Product
0961 has been discontinued. View all AMPA Receptor Antagonists products.

Key Product Details

Description

Non-competitive AMPA antagonist

View all AMPA Receptor Antagonists »

Product Description

Novel, potent, non-competitive AMPA receptor antagonist (IC50 = 2.8 μM ). Acts allosterically at the same regulatory site as GYKI 52466 (Cat. No. 1454) and GYKI 53655 (Cat. No. 2555) and other benzodiazepines but does not bind to the central diazepine binding site. Selective for AMPA relative to kainate receptor sub-types. Similar potency to GYKI 53655. Anticonvulsant in vivo.

Licensing Information

Sold with the permission of Annovis Inc.

Product Specifications

Molecular Weight

366.42

Formula

C20H22N4O3

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

(±)-4-(4-Aminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylenedioxyphthalazine

CAS Number

173952-44-8

PubChem ID

5039877

InChI Key

OFUDZKKOKPGXOH-UHFFFAOYSA-N

SMILES

CCCNC(=O)N1N=C(C2=CC=C(N)C=C2)C2=C(C=C3OCOC3=C2)C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.64 100
Ethanol 36.64 100

Preparing Stock Solutions for SYM 2206

The following data is based on the product molecular weight 366.42

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.65 mL 27.29 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.36 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for SYM 2206

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SYM 2206

For research use only

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