GYKI 53655 hydrochloride

Name: GYKI 53655 hydrochloride
Brand: Tocris Bioscience
SKU: 2555
Price: 271 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 2555

Citations (11)

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Key Product Details

Description:	Non-competitive non-NMDA iGluR antagonist
Chemical Name:	1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	388.85

View Full Technical Details for GYKI 53655 hydrochloride

Biological Activity for GYKI 53655 hydrochloride

GYKI 53655 hydrochloride is a non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 (Cat. No. 1454). Prolongs the survival time after MgCl₂- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC₅₀ = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC₅₀ = 32 μM) at high concentrations.

Technical Data for GYKI 53655 hydrochloride

M. Wt	388.85
Formula	C₁₉H₂₀N₄O₃.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	143692-48-2
PubChem ID	126757
InChi Key	ASLCSBBDVWPSQT-UHFFFAOYSA-N
Smiles	CC(N(C(NC)=O)N=C3C4=CC=C(N)C=C4)CC1=C3C=C(OCO2)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GYKI 53655 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	38.88	100
	DMSO	38.88	100

Preparing Stock Solutions for GYKI 53655 hydrochloride

The following data is based on the product molecular weight 388.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.86 mL	25.72 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.29 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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References for GYKI 53655 hydrochloride

References are publications that support the biological activity of the product.

Perrais Antagonism of recombinant and native GluK3-containing kainate receptors. Neuropharmacology 2009 PMID: 18761361
Szabados Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. Brain Res.Bull. 2001 PMID: 11489346
Paternain Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons. Neuron 1995 PMID: 7826635

Citations for GYKI 53655 hydrochloride (11)

Showing 1 - 10 of 11 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for GYKI 53655 hydrochloride include:

Droste et al. (2017) Ca2+-permeable AMPA receptors in mouse olfactory bulb astrocytes. Sci Rep. 7:44817
PMID: 28322255
Lu et al. (2017) Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters. Neuron. 96:73
PMID: 28919175
Astorga et al. (2015) An excitatory GABA loop operating in vivo. Front Cell Neurosci. 9:275
PMID: 26236197
Ben-Simon et al. (2015) A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity. PLoS One. 12:396
PMID: 26166572
Murphy-Baum and Taylor (2015) The Synaptic and Morphological Basis of Orientation Selectivity in a Polyaxonal Amacrine Cell of the Rabbit Retina. J Neurosci. 35:13336
PMID: 26424882
Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. Pharmacol Res Perspect. 10:e0131430
PMID: 26102354
Höft et al. (2014) Heterogeneity in expression of functional ionotropic glutamate and GABA receptors in astrocytes across brain regions: insights from the thalamus. Philos Trans R Soc Lond B Biol Sci. 369:20130602
PMID: 25225096
Buldyrev et al. (2012) Synaptic pathways that shape the excitatory drive in an OFF retinal ganglion cell. J Neurophysiol. 107:1795
PMID: 22205648
Straub et al. (2011) Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1. Nat Neurosci. 14:866
PMID: 21623363
Tang et al. (2011) Neto1 is an auxiliary subunit of native synaptic kainate receptors. Cell Rep. 31:10009
PMID: 21734292
Biase et al. (2010) Excitability and synaptic communication within the oligodendrocyte lineage. J Neurosci. 30:3600
PMID: 20219994

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