PPY A
Tocris Bioscience, part of Bio-Techne | Catalog # 4730
Potent inhibitor of Abl T315l mutant and wild-type Abl kinases
Key Product Details
Description
Potent inhibitor of Abl T315l mutant and wild-type Abl kinases
Product Description
PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinases (IC50 values are 9 and 20 nM, respectively). Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene.Product Specifications
Molecular Weight
372.42
Formula
C22H20N4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide
CAS Number
875634-01-8
PubChem ID
16750094
InChI Key
GYQRHHQPEMOLKH-UHFFFAOYSA-N
SMILES
O=C(N(C)C)C1=CN=CC(C2=CN=C(NC=C3C4=C(OC)C=CC=C4)C3=C2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.24 | 100 |
Preparing Stock Solutions
for PPY A
The following data is based on the product molecular weight 372.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.69 mL | 13.43 mL | 26.85 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.37 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.69 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Noronha Inhibitors of ABL and the ABL-T315I mutation. Curr.Top.Med.Chem. 2008 PMID: 18673174
- Zhou Crystal structure of the T315I mutant of AbI kinase. Chem.Biol.Drug.Des. 2007 PMID: 17718712
Product Specific Notices for PPY A
For research use only
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