L-748,337
Tocris Bioscience, part of Bio-Techne | Catalog # 2760
Selective β3 antagonist
Key Product Details
Description
Selective β3 antagonist
Product Description
L-748,337 is a competitive β3-adrenoceptor antagonist that displays selectivity over β1 and β2 receptors (Ki values are 4.0, 204 and 390 nM for β3-, β2- and β1-adrenoceptors respectively). Inhibits cAMP accumulation in response to Isoproterenol (IC50 = 6 nM). Reduces iNOS expression, attenuates nitric oxide-induced cell proliferation and induces apoptosis in a melanoma cell line.Product Specifications
Molecular Weight
497.61
Formula
C26H31N3O5S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[[3-[(2S)-2-Hydroxy-3-[[2-[4-[(phenylsulfonyl)amino]phenyl]ethyl]amino]propoxy]phenyl]methyl]-acetamide
CAS Number
244192-94-7
PubChem ID
10028830
InChI Key
AWIONHVPTYTSHZ-DEOSSOPVSA-N
SMILES
O[C@H](COC2=CC=CC(CNC(C)=O)=C2)CNCCC1=CC=C(NS(=O)(C3=CC=CC=C3)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.76 | 100 | |
| Ethanol | 4.98 | 10 |
Preparing Stock Solutions
for L-748,337
The following data is based on the product molecular weight 497.61
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.01 mL | 10.05 mL | 20.10 mL |
| 5 mM | 0.40 mL | 2.01 mL | 4.02 mL |
| 10 mM | 0.20 mL | 1.00 mL | 2.01 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Neidhold The function of α- and β-adrenoceptors of the saphenous artery in caveolin-1 knockout and wild-type mice. Br.J.Pharmacol. 2007 PMID: 17179950
- Dal Monte β3-adrenergic receptor activity modulates melanoma cell proliferation and survival through nitric oxide signaling. Naunyn Schmiedebergs Arch.Pharmacol. 2014 PMID: 24599317
- Candelore Potent and selective human β3-adrenergic receptor antagonist. J.Pharmacol.Exp.Ther. 1999 PMID: 10411574
Product Specific Notices for L-748,337
For research use only
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