(1S,3R)-ACPD
Tocris Bioscience, part of Bio-Techne | Catalog # 0284
Group I and group II mGlu agonist; active isomer of (±)-trans-ACPD (Cat. No. 0187)
Discontinued Product
0284 has been discontinued.
View all Group I mGluR Agonists products.
Key Product Details
Description
Group I and group II mGlu agonist; active isomer of (±)-trans-ACPD (Cat. No. 0187)
Product Description
(1S,3R)-ACPD is an active isomer of (±)-trans-ACPD. Agonist at both group I and II mGlu receptors (EC50 values are 5, 15, 42 and 60 μM at mGluR2, mGluR5, mGluR1 and mGluR6 respectively).NPEC-caged-(1S,3R)-ACPD, (±)-trans-ACPD and cis-ACPD also available.
Product Specifications
Molecular Weight
173.17
Formula
C7H11NO4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid
CAS Number
111900-32-4
PubChem ID
104766
InChI Key
YFYNOWXBIBKGHB-FBCQKBJTSA-N
SMILES
N[C@]1([C@@](O)=O)C[C@]([H])([C@](O)=O)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 5.2 | 30 |
Preparing Stock Solutions
for (1S,3R)-ACPD
The following data is based on the product molecular weight 173.17
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.3 mM | 19.25 mL | 96.24 mL | 192.49 mL |
| 1.5 mM | 3.85 mL | 19.25 mL | 38.50 mL |
| 3 mM | 1.92 mL | 9.62 mL | 19.25 mL |
| 15 mM | 0.38 mL | 1.92 mL | 3.85 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Knopfel Metabotropic glutamate receptors: novel targets for drug development. J.Med.Chem. 1995 PMID: 7738999
- Mistry and Challis Differences in agonist and antagonist activities for two indicies of metabotropic glutamate receptor-stimulated phosphoinositide turnover. Br.J.Pharmacol. 1996 PMID: 8732284
- Conti Synthesis and pharmacology of 3-hydroxy-⏊-isoxazoline-cyclopentance analogues of glutamic acid. Farmaco 2002 PMID: 12484537
Product Specific Notices for (1S,3R)-ACPD
For research use only
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