cis-ACPD

Name: cis -ACPD
Brand: Tocris Bioscience
SKU: 0186

Tocris Bioscience, part of Bio-Techne | Catalog # 0186

COA / SDS

Potent NMDA agonist; also group II mGluR agonist

Discontinued Product

0186 has been discontinued. View all NMDA Receptor Agonists products.

Key Product Details

Description:	Potent NMDA agonist; also group II mGluR agonist
Chemical Name:	(±)-1-Aminocyclopentane-cis-1,3-dicarboxylic acid
Molecular Weight:	173.17

View Full Technical Details for cis-ACPD

Technical Data
Citations

Biological Activity for cis-ACPD

cis-ACPD is a 1:1 mixture of (1R,3R)- and (1S,3S)-ACPD. Potent NMDA receptor agonist and selective group II mGluR agonist (EC₅₀ values are 13, 50, >300 and >300 μM at mGluR₂, mGluR₄, mGluR₁ and mGluR₅ respectively). Exhibits proconvulsant activity in vivo.

(±)-trans-ACPD and (1S,3R)-ACPD also available.

Technical Data for cis-ACPD

M. Wt	173.17
Formula	C₇H₁₁NO₄
Storage	Store at RT
CAS Number	477331-06-9
PubChem ID	16760136
InChi Key	DXLSPTHQGVGVTN-ATXZCBKLSA-N
Smiles	[H][C@@]1(CC[C@](N)(C1)C(O)=O)C(O)=O.[H][C@]1(CC[C@@](N)(C1)C(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for cis-ACPD

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH		100

Preparing Stock Solutions for cis-ACPD

The following data is based on the product molecular weight 173.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.77 mL	28.87 mL	57.75 mL
5 mM	1.15 mL	5.77 mL	11.55 mL
10 mM	0.58 mL	2.89 mL	5.77 mL
50 mM	0.12 mL	0.58 mL	1.15 mL

Molarity Calculator

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Reconstitution Calculator

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References for cis-ACPD

References are publications that support the biological activity of the product.

Schoepp In vitro and in vivo pharmacology of trans- and cis-(±)-1-amino-1,3-cyclopentanedicarboxylic acid: Dissociation of metabotropic and ionotropic excitatory amino acid receptor effects. J.Neurochem. 1991 PMID: 1849553
Sunter Actions of the four isomers of 1-aminocyclopentane-1,3-dicarboxylate (ACPD) in the hemisected spinal cord of the neonatal rat. Br.J.Pharmacol.
Conti Synthesis and pharmacology of 3-hydroxy-Δ²-isoxazoline-cyclopentane analogues of glutamic acid. Farmaco 2002 PMID: 12484537