(1S,3R)-ACPD

Name: (1 S ,3 R )-ACPD
Brand: Tocris Bioscience
SKU: 0284

Catalog # 0284

Citations (6)

COA / SDS

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Key Product Details

Description:	Group I and group II mGlu agonist; active isomer of (±)-trans-ACPD (Cat. No. 0187)
Chemical Name:	(1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	173.17

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Biological Activity

(1S,3R)-ACPD is an active isomer of (±)-trans-ACPD. Agonist at both group I and II mGlu receptors (EC₅₀ values are 5, 15, 42 and 60 μM at mGluR₂, mGluR₅, mGluR₁ and mGluR₆ respectively).

NPEC-caged-(1S,3R)-ACPD, (±)-trans-ACPD and cis-ACPD also available.

Technical Data

M. Wt	173.17
Formula	C₇H₁₁NO₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	111900-32-4
PubChem ID	104766
InChi Key	YFYNOWXBIBKGHB-FBCQKBJTSA-N
Smiles	N[C@]1([C@@](O)=O)C[C@]([H])([C@](O)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	5.2	30

Preparing Stock Solutions

The following data is based on the product molecular weight 173.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.3 mM	19.25 mL	96.24 mL	192.49 mL
1.5 mM	3.85 mL	19.25 mL	38.50 mL
3 mM	1.92 mL	9.62 mL	19.25 mL
15 mM	0.38 mL	1.92 mL	3.85 mL

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References

References are publications that support the biological activity of the product.

Conti Synthesis and pharmacology of 3-hydroxy-Δ²-isoxazoline-cyclopentance analogues of glutamic acid. Farmaco 2002 PMID: 12484537
Mistry and Challis Differences in agonist and antagonist activities for two indicies of metabotropic glutamate receptor-stimulated phosphoinositide turnover. Br.J.Pharmacol. 1996 PMID: 8732284
Knopfel Metabotropic glutamate receptors: novel targets for drug development. J.Med.Chem. 1995 PMID: 7738999

Citations for (1<em>S</em>,3<em>R</em>)-ACPD (6)

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Citations are publications that use Bio-Techne products. Selected citations for (1S,3R)-ACPD include:

Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol. 13(4):372
PMID: 28135236
Tang et al. (2015) Stimulation-evoked Ca²⁺ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. J Neurosci. 35:3016
PMID: 25698739
Andlauer et al. (2014) Drep-2 is a novel synaptic protein important for learning and memory. J Neurosci. 3
PMID: 25392983
Pasquale and Sherman (2013) A modulatory effect of the feedback from higher visual areas to V1 in the mouse. J Neurophysiol. 109:2618
PMID: 23446698
Yamada et al. (2008) Long-range axonal calcium sweep induces axon retraction. Sci Adv. 28:4613
PMID: 18448637
Blanco et al. (2008) Tone-dependent vascular responses to astrocyte-derived signals. Am J Physiol Heart Circ Physiol. 294:H2855
PMID: 18456724

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