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Key Product Details
Description: | Potent and highly selective A2A antagonist |
Chemical Name: | 4-(2-[7-Amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 337.34 |
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Citations (106)
Citations are publications that use Bio-Techne products. Selected citations for ZM 241385 include:
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Ryzhov et al.
(2019)
Number of Circulating CD 73-Expressing Lymphocytes Correlates With Survival After Cardiac Arrest.
J Am Heart Assoc.
8:e010874
PMID: 31237169 -
Nuccio et al.
(2019)
Adenosine A2A receptor stimulation restores cell functions and differentiation in Niemann-Pick type C-like oligodendrocytes.
Sci Rep.
9:9782
PMID: 31278313 -
Hirata et al.
(2018)
CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.
Cell Stem Cell.
22:445
PMID: 29456159 -
Ng
(2018)
Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells.
Cell Signal.
51:59
PMID: 30076967 -
Wakisaka et al.
(2017)
An Adenosine Receptor for Olfaction in Fish.
Curr Biol.
27:1437
PMID: 28502661 -
Liu et al.
(2016)
Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome.
Scientific Reports.
6:33614
PMID: 27647162 -
Mediero et al.
(2016)
Ticagrelor regulates osteoblast and osteoclast function and promotes bone formation in vivo via an adenosine-dependent mechanism.
FASEB J..
2016;
PMID: 27511945 -
Caiazzo et al.
(2016)
Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide.
Biochem.Pharmacol..
112:72
PMID: 27188793 -
Stoddart et al.
(2015)
Application of BRET to monitor ligand binding to GPCRs.
Nat Methods.
12:661
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Hegde et al.
(2015)
Critical Role of Mast Cells and Peroxisome Proliferator-Activated Receptor γ in the Induction of Myeloid-Derived Suppressor Cells by Marijuana Cannabidiol In Vivo.
J Immunol.
194:5211
PMID: 25917103 -
Cunha et al.
(2015)
Creatine, similarly to KA, affords antidepressant-like effects in the tail suspension test via adenosine A1 and A2A receptor activation.
Biochem J.
11:215
PMID: 25702084 -
Tosolini et al.
(2015)
Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a Gαs protein-coupled receptor tonic inhibition of mitochondrially induced cell death.
Am J Physiol Lung Cell Mol Physiol.
35:479
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Jamshad et al.
(2015)
G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent.
Mol Cell Biol.
35
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Kohno et al.
(2015)
Anti-inflammatory effects of adenosine N1-oxide.
Biosci Rep.
12:2
PMID: 25632271 -
Oliveira et al.
(2015)
Deficits in endogenous adenosine formation by ecto-5'-nucleotidase/CD73 impair neuromuscular transmission and immune competence in experimental autoimmune myasthenia gravis.
Mediators Inflamm.
2015:460610
PMID: 25691808 -
Perez-Aso et al.
(2015)
Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors.
Arthritis Res Ther.
17:249
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Perígolo-Vicente et al.
(2014)
IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection.
Biochem Biophys Res Commun.
449:477
PMID: 24845382 -
Ruby et al.
(2014)
Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light.
Kidney Int.
39:2432
PMID: 24755889 -
Welihinda and Amento et al.
(2014)
Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation.
J Inflamm (Lond).
11:37
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Chiodi et al.
(2014)
Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP.
Neuropsychopharmacology.
39:569
PMID: 23989619 -
Ahsan and Mehal
(2014)
Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb.
Front Pharmacol.
5:69
PMID: 24782773 -
Sassi et al.
(2014)
Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.
J Clin Invest.
124:5385
PMID: 25401477 -
Mediavilla-Varela et al.
(2013)
Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth.
Neuropsychopharmacology.
14:860
PMID: 23917542 -
Hein et al.
(2013)
Cellular signalling pathways mediating dilation of porcine pial arterioles to adenosine A2A receptor activation.
Blood.
99:156
PMID: 23539502 -
Nam et al.
(2013)
Adenosine transporter ENT1 regulates the acquisition of goal-directed behavior and ethanol drinking through A2A receptor in the dorsomedial striatum.
J Neurosci.
33:4329
PMID: 23467349 -
Jenabian et al.
(2013)
Regulatory T cells negatively affect IL-2 production of effector T cells through CD39/adenosine pathway in HIV infection.
PLoS Pathog.
9:e1003319
PMID: 23658513 -
Fernández-Dueñas et al.
(2013)
DA D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework.
Oncoimmunology.
63:42
PMID: 23619397 -
Jastrzebska et al.
(2013)
Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans.
J Neurochem.
520:239
PMID: 23332703 -
He et al.
(2013)
Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.
FASEB J.
27:3446
PMID: 23682121 -
Mandapathil et al.
(2012)
CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma.
FASEB J.
1:659
PMID: 22934258 -
Tozzi et al.
(2012)
A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation.
PLoS One.
7:e38312
PMID: 22715379 -
Jeon et al.
(2012)
Oroxylin A Induces BDNF Expression on Cortical Neurons through Adenosine A2A Receptor Stimulation: A Possible Role in Neuroprotection.
Neurochem Int.
20:27
PMID: 24116271 -
Lee et al.
(2012)
Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study.
Biomol Ther (Seoul).
63:340
PMID: 23115687 -
Williams and Cronstein
(2012)
The effect of A(2A) adenosine receptor activation on C-C chemokine receptor 7 expression in human THP1 macrophages during inflammation.
Inflammation.
35:614
PMID: 21739164 -
Lee et al.
(2012)
When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders?
PLoS One.
7:e38865
PMID: 22719969 -
Suzuki et al.
(2012)
CD8+CD45RA+CCR7+FOXP3+ T cells with immunosuppressive properties: a novel subset of inducible human regulatory T cells.
J Immunol.
189:2118
PMID: 22821963 -
Fernández-Dueñas et al.
(2012)
Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R.
Invest Ophthalmol Vis Sci.
123:373
PMID: 22924752 -
Kinsey et al.
(2012)
Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection.
J Am Soc Nephrol.
23:1528
PMID: 22835488 -
Golembiowska and Dziubina
(2012)
The effect of adenosine A(2A) receptor antagonists on hydroxyl radical, DA, and glutamate in the striatum of rats with altered function of VMAT2.
Neurotox Res.
22:150
PMID: 22407500 -
Waickman et al.
(2012)
Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor.
Cancer Immunol Immunother.
61:917
PMID: 22116345 -
Takedachi et al.
(2012)
CD73-generated adenosine promotes osteoblast differentiation.
J Cell Physiol.
227:2622
PMID: 21882189 -
Lindquist
(2012)
Adenosine receptor activation is responsible for prolonged depression of synaptic transmission after spreading depolarization in brain slices.
Neuroscience.
223:365
PMID: 22864185 -
Stoddart et al.
(2012)
Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.
Chem Biol.
19:1105
PMID: 22999879 -
Mediero et al.
(2012)
Adenosine A2A receptor activation prevents wear particle-induced osteolysis.
Sci Transl Med.
4:135ra65
PMID: 22623741 -
Kiebala and Maggirwar
(2011)
Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells.
PLoS One.
6:e18633
PMID: 21494611 -
Jin et al.
(2011)
Paeoniflorin suppresses the expression of intercellular adhesion molecule-1 (ICAM-1) in endotoxin-treated human monocytic cells.
Br J Pharmacol.
164:694
PMID: 21542832 -
Tozzi et al.
(2011)
The distinct role of medium spiny neurons and cholinergic interneurons in the D2/A2A receptor interaction in the striatum: implications for Parkinson's disease.
J Neurosci.
31:1850
PMID: 21289195 -
Garcia et al.
(2011)
Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation.
Proc Natl Acad Sci U S A.
80:378
PMID: 21508927 -
Ruiz-García et al.
(2011)
Cooperation of adenosine with macrophage Toll-4 receptor agonists leads to increased glycolytic flux through the enhanced expression of PFKFB3 gene.
J Biol Chem.
286:19247
PMID: 21464136 -
Zhukov et al.
(2011)
Biophysical mapping of the adenosine A2A receptor.
J Med Chem.
54:4312
PMID: 21661720 -
Gebremedhin et al.
(2010)
Adenosine can mediate its actions through generation of reactive oxygen species.
J Cereb Blood Flow Metab.
30:1777
PMID: 20531463 -
Himer et al.
(2010)
Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death.
FASEB J.
24:2631
PMID: 20371613 -
Gazoni et al.
(2010)
Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury.
J Thorac Cardiovasc Surg.
140:440
PMID: 20398911 -
Bingham et al.
(2010)
A2A adenosine receptor stimulation decreases foam cell formation by enhancing ABCA1-dependent cholesterol efflux.
J Leukoc Biol.
87:683
PMID: 20089670 -
Nowak et al.
(2010)
The A2aR adenosine receptor controls cytokine production in iNKT cells.
Am J Pathol.
40:682
PMID: 20039304 -
Long et al.
(2010)
Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine.
J Exp Med.
335:781
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Paisansathan et al.
(2010)
Interactions between adenosine and K+ channel-related pathways in the coupling of somatosensory activation and pial arteriolar dilation.
Am J Physiol Heart Circ Physiol.
299:H2009
PMID: 20889844 -
Wang et al.
(2010)
Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385.
Korean J Anesthesiol.
5:e13883
PMID: 21079735 -
Riccioni et al.
(2010)
Adenosine A(2A) Receptor Binding Profile of Two Antagonists, ST1535 and KW6002: Consideration on the Presence of Atypical Adenosine A(2A) Binding Sites.
Front Psychiatry.
1:22
PMID: 21423433 -
Carlström et al.
(2010)
Adenosine A(2) receptors modulate tubuloglomerular feedback.
Am J Physiol Renal Physiol.
299:F412
PMID: 20519378 -
Mandapathil et al.
(2010)
Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells.
J Biol Chem.
285:7176
PMID: 19858205 -
Pugliese et al.
(2009)
The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices.
Br J Pharmacol.
157:818
PMID: 19422385 -
Epperson et al.
(2009)
Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts.
Am J Physiol Cell Physiol.
296:C1171
PMID: 19244482 -
Clark et al.
(2009)
Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation.
J Neurosci.
29:11237
PMID: 19741130 -
Alam et al.
(2009)
A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence.
Mucosal Immunol.
2:232
PMID: 19262506 -
Yu et al.
(2009)
Effect of ventilation pressure on alveolar fluid clearance and β-agonist responses in mice.
Cancer Biol Ther.
297:L785
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Ohta et al.
(2009)
A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironments.
Cardiovasc Res.
183:5487
PMID: 19843934 -
Wilson et al.
(2009)
The A2B adenosine receptor impairs the maturation and immunogenicity of dendritic cells.
J Immunol.
182:4616
PMID: 19342636 -
Maeda and Koos
(2009)
Adenosine A1 and A2a receptors modulate Insemia, glycemia, and lactatemia in fetal sheep.
Proc Natl Acad Sci U S A.
296:R693
PMID: 19118101 -
Shi et al.
(2008)
Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex.
J Cereb Blood Flow Metab.
28:111
PMID: 17519974 -
Csóka et al.
(2008)
Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function.
FASEB J.
22:3491
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Fernandez et al.
(2008)
Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine.
J Pharmacol Exp Ther.
172:1675
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Garcia et al.
(2008)
Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis.
Am J Physiol Regul Integr Comp Physiol.
22:445
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Singh et al.
(2008)
Large-scale functional expression of WT and truncated human adenosine A2A receptor in Pichia pastoris bioreactor cultures.
Eur J Immunol.
7:28
PMID: 18847468 -
Liou et al.
(2008)
Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor.
PLoS One.
49:5526
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Ramanathan et al.
(2007)
Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter.
Br J Pharmacol.
18:14
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Chan et al.
(2006)
Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis.
Br J Pharmacol.
148:1144
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Zhang et al.
(2006)
Adenosine A2a receptors induce heterologous desensitization of chemokine receptors.
Microb Cell Fact.
108:38
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Ge et al.
(2006)
Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor.
J Inflamm (Lond).
319:1200
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Lappas et al.
(2006)
Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation.
Mol Biol Cell.
203:2639
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Bertarelli et al.
(2006)
Characterization of human and rodent native and recombinant adenosine A(2B) receptors by radioligand binding studies.
Purinergic Signal.
2:559
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Jacobson et al.
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A neoceptor approach to unraveling microscopic interactions between the human A2A adenosine receptor and its agonists.
Chem Biol.
12:237
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Murphree et al.
(2005)
Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-κB in A(2A) adenosine receptor induction.
Methods Enzymol.
391:575
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Erdmann et al.
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Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo.
J Pharmacol Exp Ther.
105:4707
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Kornerup et al.
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Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge.
Br J Pharmacol.
144:1011
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Newman
(2005)
Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
Blood.
25:5502
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Fresco et al.
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Facilitation of noradrenaline release by activation of adenosine A(2A) receptors triggers both phospholipase C and adenylate cyclase pathways in rat tail artery.
Cardiovasc Res.
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Yip
(2004)
Role of adenosine A2A receptor in the regulation of gastric somatostatin release.
J Pharmacol Exp Ther.
309:804
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Germack and Dickenson
(2004)
Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes.
Br J Pharmacol.
141:329
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Wen and Knowles
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Extracellular ATP and adenosine induce cell apoptosis of human hepatoma Li-7A cells via the A3 adenosine receptor.
Br J Pharmacol.
140:1009
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Neuroprotection by caffeine and adenosine A2A receptor blockade of β-amyloid neurotoxicity.
PLoS One.
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Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.
Br J Pharmacol.
100:1322
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2-Chloroadenosine but not adenosine induces apoptosis in rheumatoid fibroblasts independently of cell surface adenosine receptor signalling.
Br J Pharmacol.
135:1477
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Brito et al.
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Adenosine A(2A) receptors in portal hypertension: their role in the abnormal response to adenosine of the cranial mesenteric artery in rabbits.
J Neurosci.
135:1324
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Hirsh and Silinsky
(2002)
Inhibition of spontaneous acetylcholine secretion by 2-chloroadenosine as revealed by a protein kinase inhibitor at the mouse neuromuscular junction.
Br J Pharmacol.
135:1897
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Slesinger
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British Pharmacological Society Meeting. 18-21 December 2000, University of Birmingham. Abstracts.
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133 Suppl:1P
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A(1)-, A(2A)- and A(3)-subtype adenosine receptors modulate intraocular pressure in the mouse.
Br J Pharmacol.
134:241
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Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO.
Br J Pharmacol.
134:745
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Lee and Chao
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Activation of Trk neurotrophin receptors in the absence of neurotrophins.
Purinergic Signal.
98:3555
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Anderson et al.
(2000)
Accelerated resequestration of cytosolic calcium and suppression of the pro-inflammatory activities of human neutrophils by CGS 21680 in vitro.
Br J Pharmacol.
130:717
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Haynes
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A(2A) adenosine receptor mediated potassium channel activation in rat epididymal smooth muscle.
Br J Pharmacol.
130:685
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Hernandez et al.
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A2B adenosine receptors mediate relaxation of the pig intravesical ureter: adenosine modulation of non adrenergic non cholinergic excitatory neurotransmission.
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126:969
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Effect of A2A adenosine receptor stimulation and antagonism on synaptic depression induced by in vitro ischaemia in rat hippocampal slices.
Br J Pharmacol.
128:1035
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A1 and A2 adenosine receptor modulation of contractility in the cauda epididymis of the guinea-pig.
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125:570
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Guibert et al.
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Dependence of P2-nucleotide receptor agonist-mediated endothelium-independent relaxation on ectonucleotidase activity and A2A-receptors in rat portal vein.
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Anti-inflammatory preconditioning by agonists of adenosine A1 receptor.
J Immunol.
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There are no citations that match your criteria.
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Species: MouseAssay Type: Ex VivoCell Line/Tissue: solenocytesMouse solenocytes were activated with antiCD3/28 and treated with 5 uM of ZM241385 in presence or absence of CGS21680. After 24 hours the supernatant was collected, and IFN-gamma was measured by ELISA.
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