Tocris Bioscience a Bio-Techne Brand
Key Product Details
|Description:||Inhibitor of SOCE in non-excitable cells|
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Citations for YM 58483 (2)
Citations are publications that use Bio-Techne products. Selected citations for YM 58483 include:
Gao et al.
A store-operated calcium channel inhibitor attenuates collagen-induced arthritis.
Br J Pharmacol.
Gao et al.
Potent analgesic effects of a store-operated calcium channel inhibitor.
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Customer Reviews for YM 58483 (3)
Species: HumanAssay Type: In VitroCell Line/Tissue: LAD2 - mast cellsYM 58483 was used to study the role of the MRGPRX2 receptor in store-operated calcium entry using human mast cells (LAD2 cells). At a concentration of 0.3 and 1 uM of YM58483 inhibited the calcium entry induced by cortistatin in mast cells.
Species: HumanAssay Type: In VitroCell Line/Tissue: HEK293HEK293 cells were incubated with intracellular Ca2+ sensitive dye, Fura-2AM in normal tyrode solution for 40 min, washed and kept aside for 20 min. Fura2-loaded cells were excited alternately at 340 and 380 nm and fluorescence at 510 nm was expressed as 340/380 ratio. Intracellular Ca2+ stores were depleted with 30 μM BHQ which promotes store-operated Ca2+ entry into the cells upon addition of 1 mM extracellular Ca2+. Preincubation of cells with 10 μM BTP2 (YM 58483) for 10 min attenuates this Ca2+ entry.
Species: MouseAssay Type: Ex VivoCell Line/Tissue: Brain sliceUsed to block SOCE mechanism but no effect was seen. Unsure about efficacy of the compound, it might be a lack of SOCE involvement in the biological process studied here.
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