YM 58483 is a blocker of store-operated Ca²⁺ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes). Inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin-induced sustained Ca²⁺ influx (IC₅₀ = 100 nM). Displays immuno-modulatory and anti-inflammatory effects; suppresses cytokine production and proliferation of T cells in vitro.

Product Specifications

Molecular Weight

421.32

Formula

C₁₅H₉F₆N₅OS

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide

CAS Number

223499-30-7

PubChem ID

2455

InChI Key

XPRZIORDEVHURQ-UHFFFAOYSA-N

SMILES

O=C(C3=C(C)N=NS3)NC1=CC=C(N2N=C(C(F)(F)F)C=C2C(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.13	100
	Ethanol	42.13	100

Preparing Stock Solutions for YM 58483

The following data is based on the product molecular weight 421.32

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.87 mL	23.73 mL
5 mM	0.47 mL	2.37 mL	4.75 mL
10 mM	0.24 mL	1.19 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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Background References

References are publications that support the biological activity of the product.

Zitt Potent inhibition of Ca²⁺ release-activated Ca²⁺ channels and T-lymphocyte activation by the pyrazole derivative BTP2. J.Biol.Chem. 2004 PMID: 14718545
Ohga Characterization of YM-58483/BTP2, a novel store-operated Ca²⁺ entry blocker, on T cell-mediated immune responses in vivo. Int.Immunopharmocol. 2008 PMID: 18793756
Ishikawa A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca²⁺ influx and IL-2 production in T lymphocytes. J.Immunol. 2003 PMID: 12707319

YM 58483

Tocris Bioscience, part of Bio-Techne | Catalog # 3939

Key Product Details

Description

Alternative Names

View all Other Calcium Channel Inhibitors »

Product Description