YM 58483

Name: YM 58483
Brand: Tocris Bioscience
SKU: 3939
Rating: 4 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3939

(3)

Citations (41)

COA / SDS

Inhibitor of SOCE in non-excitable cells

Key Product Details

Description:	Inhibitor of SOCE in non-excitable cells
Alternative Names:	Btp2
Chemical Name:	N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	421.32

View Full Technical Details for YM 58483

Technical Data
Citations / Reviews (3)

Biological Activity for YM 58483

YM 58483 is a blocker of store-operated Ca²⁺ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes). Inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin-induced sustained Ca²⁺ influx (IC₅₀ = 100 nM). Displays immuno-modulatory and anti-inflammatory effects; suppresses cytokine production and proliferation of T cells in vitro.

Compound Libraries for YM 58483

YM 58483 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for YM 58483

M. Wt	421.32
Formula	C₁₅H₉F₆N₅OS
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	223499-30-7
PubChem ID	2455
InChi Key	XPRZIORDEVHURQ-UHFFFAOYSA-N
Smiles	O=C(C3=C(C)N=NS3)NC1=CC=C(N2N=C(C(F)(F)F)C=C2C(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for YM 58483

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.13	100
	ethanol	42.13	100

Preparing Stock Solutions for YM 58483

The following data is based on the product molecular weight 421.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.87 mL	23.73 mL
5 mM	0.47 mL	2.37 mL	4.75 mL
10 mM	0.24 mL	1.19 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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References for YM 58483

References are publications that support the biological activity of the product.

Zitt Potent inhibition of Ca²⁺ release-activated Ca²⁺ channels and T-lymphocyte activation by the pyrazole derivative BTP2. J.Biol.Chem. 2004 PMID: 14718545
Ohga Characterization of YM-58483/BTP2, a novel store-operated Ca²⁺ entry blocker, on T cell-mediated immune responses in vivo. Int.Immunopharmocol. 2008 PMID: 18793756
Ishikawa A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca²⁺ influx and IL-2 production in T lymphocytes. J.Immunol. 2003 PMID: 12707319