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YM 58483

Tocris Bioscience a Bio-Techne Brand

YM 58483 | CAS No. 223499-30-7 | Inhibitor of SOCE in non-excitable cells
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Key Product Details

Description: Inhibitor of SOCE in non-excitable cells
Alternative Names: Btp2
Chemical Name: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide
Purity: ≥99% (HPLC)
Molecular Weight: 421.32

Citations for YM 58483 (2)

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Customer Reviews for YM 58483 (3)

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  • Inhibits calcium entry in mast cells.
    Name: ANANTH KUMAR KAMMALA
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: LAD2 - mast cells
    YM 58483 was used to study the role of the MRGPRX2 receptor in store-operated calcium entry using human mast cells (LAD2 cells). At a concentration of 0.3 and 1 uM of YM58483 inhibited the calcium entry induced by cortistatin in mast cells.
    YM 58483 Serum 3939
  • BTP2 attenuates store-operated Ca2+ entry
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK293
    HEK293 cells were incubated with intracellular Ca2+ sensitive dye, Fura-2AM in normal tyrode solution for 40 min, washed and kept aside for 20 min. Fura2-loaded cells were excited alternately at 340 and 380 nm and fluorescence at 510 nm was expressed as 340/380 ratio. Intracellular Ca2+ stores were depleted with 30 μM BHQ which promotes store-operated Ca2+ entry into the cells upon addition of 1 mM extracellular Ca2+. Preincubation of cells with 10 μM BTP2 (YM 58483) for 10 min attenuates this Ca2+ entry.
    YM 58483 Serum 3939
  • Store-operated calcium entry blocker
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: Brain slice
    Used to block SOCE mechanism but no effect was seen. Unsure about efficacy of the compound, it might be a lack of SOCE involvement in the biological process studied here.

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Product Documents for YM 58483

Certificate of Analysis

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