Wiskostatin

Tocris Bioscience, part of Bio-Techne | Catalog # 4434

N-WASP inhibitor; inhibits Arp2/3 activation
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Key Product Details

Description

N-WASP inhibitor; inhibits Arp2/3 activation

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Product Description

Wiskostatin is an inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Interacts with the regulatory GTPase-binding domain of N-WASP; inhibits activation of Arp2/3 complex by maintaining N-WASP in an inactive conformation. Also inhibits PIP2-induced actin polymerization (EC50 ~ 4μM).

Product Specifications

Molecular Weight

426.15

Formula

C17H18Br2N2O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol

CAS Number

253449-04-6

PubChem ID

2775510

InChI Key

XUBJEDZHBUPBKL-UHFFFAOYSA-N

SMILES

BrC(C=C3)=CC1=C3N(CC(O)CN(C)C)C2=C1C=C(Br)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.62 100

Preparing Stock Solutions for Wiskostatin

The following data is based on the product molecular weight 426.15

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.73 mL 23.47 mL
5 mM 0.47 mL 2.35 mL 4.69 mL
10 mM 0.23 mL 1.17 mL 2.35 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Wiskostatin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Wiskostatin

For research use only

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