ω-Conotoxin GVIA

Name: ω-Conotoxin GVIA
Brand: Tocris Bioscience
SKU: 1085
Rating: 5 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1085

(3)

Citations (31)

COA / SDS

CaV2.2 blocker

Key Product Details

Description:	Ca_V2.2 blocker
Purity:	≥95% (HPLC)
Molecular Weight:	3037

View Full Technical Details for ω-Conotoxin GVIA

Technical Data
Citations / Reviews (3)

Biological Activity for ω-Conotoxin GVIA

ω-Conotoxin GVIA is a peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC₅₀ = 0.15 nM). Reduces (RS)-3,5-DHPG (Cat. No. 0342)-induced long term depression in vivo.

Technical Data for ω-Conotoxin GVIA

M. Wt	3037
Formula	C₁₂₀H₁₈₂N₃₈O₄₃S₆
Single Letter Sequence	CKSXGSSCSXTSYNCCRSCNXYTKRCY (Modifications: X = Hyp, Disulfide bridges: 1-16, 8-19, 15-26, Tyr-27 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	106375-28-4
PubChem ID	90479753
InChi Key	DRVGOMCWRXUORL-QPEMYEDGSA-N
Smiles	[H]N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)C4C(O)CCN4C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CNC(=O)C4C(O)CCN4C(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](CO)C(=O)N1CCC(O)C1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N3)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ω-Conotoxin GVIA

Solubility

Soluble to 1mg/ml in water

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References for ω-Conotoxin GVIA

References are publications that support the biological activity of the product.

Sato Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels. Biochem.Biophys.Res.Comm. 1993 PMID: 8394704
Wright and Angu Prolonged cardiovascular effects of the N-type Ca²⁺ channel antagonist ω-conotoxin GVIA in conscious rabbits. J.Cardiovasc.Pharmacol. 1997 PMID: 9300325
Connelly Distinct mechanisms contribute to agonist and synaptically induced metabotropic glutamate receptor long-term depression. Eur.J.Pharmacol. 2011 PMID: 21575629
Tsien Multiple types of neuronal calcium channels and their selective modulation. TiNS 1988 PMID: 2469160