(RS)-3,5-DHPG

Name: ( RS )-3,5-DHPG
Brand: Tocris Bioscience
SKU: 0342
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0342

(2)

Citations (99)

COA / SDS

Selective group I mGlu agonist

Key Product Details

Description:	Selective group I mGlu agonist
Chemical Name:	(RS)-3,5-Dihydroxyphenylglycine
Purity:	≥99% (HPLC)
Molecular Weight:	183.16

View Full Technical Details for (RS)-3,5-DHPG

Technical Data
Citations / Reviews (2)

Biological Activity for (RS)-3,5-DHPG

(RS)-3,5-DHPG is a selective group I metabotropic glutamate receptor agonist which activates both mGlu₁ and mGlu₅. Also reported to be an antagonist at metabotropic glutamate receptors linked to phospholipase D.

S-enantiomer also available.

Technical Data for (RS)-3,5-DHPG

M. Wt	183.16
Formula	C₈H₉NO₄
Storage	Desiccate at -20°C
Purity	≥99% (HPLC)
CAS Number	146255-66-5
PubChem ID	108001
InChi Key	HOOWCUZPEFNHDT-UHFFFAOYSA-N
Smiles	NC(C(O)=O)C1=CC(O)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (RS)-3,5-DHPG

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	1.83	10

Preparing Stock Solutions for (RS)-3,5-DHPG

The following data is based on the product molecular weight 183.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	54.60 mL	272.99 mL	545.97 mL
0.5 mM	10.92 mL	54.60 mL	109.19 mL
1 mM	5.46 mL	27.30 mL	54.60 mL
5 mM	1.09 mL	5.46 mL	10.92 mL

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Reconstitution Calculator

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References for (RS)-3,5-DHPG

References are publications that support the biological activity of the product.

Palmer The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus. Neuropharmacology 1997 PMID: 9517422
Mistry Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II-selective metabotropic glutamate receptor agonists. Br.J.Pharmacol. 1998 PMID: 9504400
Pellegrini-Giampietro Pharmacological characterization of metabotropic glutamate recpetors coupled to phopholipase D in the rat hippocampus. Br.J.Pharmacol. 1996 PMID: 8799579
Ito 3,5-Dihydroxyphenylglycine: a potent agonist of metabotropic glutamate receptors. NeuroReport 1992 PMID: 1362358