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Key Product Details
| Description: | Selective group I mGlu agonist; active enantiomer of 3,5-DHPG (Cat. No. 0342) |
| Chemical Name: | (S)-3,5-Dihydroxyphenylglycine |
| Purity: | ≥98% (HPLC) |
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Showing 1-5 of 37 citations
Citations (37)
Citations are publications that use Bio-techne products. Selected citations for (S)-3,5-DHPG include:
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Paul et al.
(2019)
Differential Regulation of Syngap1 Translation by FMRP Modulates eEF2 Mediated Response on NMDAR Activity.
Front Mol Neurosci.
12:97
PMID: 31143100 -
Morel et al.
(2018)
JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory.
J Neurosci.
38:3708
PMID: 29540552 -
Hellmer et al.
(2018)
A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina.
Physiol Rep.
6:e13885
PMID: 30338673 -
Musella
(2017)
A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum.
Sci Rep.
7(1):7363
PMID: 28779174 -
Hashimotodani et al.
(2017)
LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
Neuron.
95:928
PMID: 28817805 -
Pallo et al.
(2016)
Mechanisms of tau and Aβ-induced excitotoxicity.
Brain Res.
1634:119
PMID: 26731336 -
Tang and Alger
(2015)
Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome.
J Neurosci.
35:3938
PMID: 25740522 -
Aguilar-Valles et al.
(2015)
Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2.
Neuropharmacology.
35:11125
PMID: 26245973 -
Henderson et al.
(2015)
A Low Affinity GCaMP3 Variant (GCaMPer) for Imaging the Endoplasmic Reticulum Calcium Store.
J Neurosci.
10:e0139273
PMID: 26451944 -
Ifrim et al.
(2015)
Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome.
PLoS One.
35:7116
PMID: 25948262 -
Tang et al.
(2015)
Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
J Neurosci.
35:3016
PMID: 25698739 -
Zhao
(2014)
BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling.
J Neurophysiol.
111:1008
PMID: 24335212 -
Careaga et al.
(2014)
Group I metabotropic glutamate receptor mediated dynamic immune dysfunction in children with fragile X syndrome.
J Neuroinflammation.
11:110
PMID: 24942544 -
Pollard et al.
(2014)
Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator.
J Psychopharmacol.
28:935
PMID: 25031220 -
McQuail et al.
(2013)
Hippocampal Gαq/11 but not Gαo-coupled receptors are altered in aging.
PLoS One.
70:63
PMID: 23347951 -
Kuribayashi et al.
(2013)
The role of metabotropic glutamate receptor 5 on the stromal cell-derived factor-1/CXCR4 system in oral cancer.
J Biol Chem.
8:e80773
PMID: 24236200 -
Fairless et al.
(2013)
Membrane potential measurements of isolated neurons using a voltage-sensitive dye.
PLoS One.
8:e58260
PMID: 23516458 -
Gregg et al.
(2012)
Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia.
J Neurosci.
32:9457
PMID: 22787031 -
Bozdagi et al.
(2012)
Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice.
J Neurosci.
7:e42422
PMID: 22900020 -
Peterfi et al.
(2012)
Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons.
J Neurosci.
32:14448
PMID: 23055515 -
Taman and Ribeiro
(2011)
Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni.
PLoS One.
6:e27119
PMID: 22069494 -
Zhao et al.
(2011)
Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus.
J Neurosci.
31:725
PMID: 21228181 -
Pan et al.
(2010)
Ictal activity induced by group I metabotropic glutamate receptor activation and loss of afterhyperpolarizations.
Neuropharmacology.
59:86
PMID: 20385148 -
Fu and Pol
(2010)
Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism.
J Neurosci.
30:10205
PMID: 20668204 -
Filippov et al.
(2010)
The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons.
Mol Pharmacol.
30:11068
PMID: 20720114 -
Westmark and Malter
(2007)
FMRP mediates mGluR5-dependent translation of amyloid precursor protein.
PLoS Biol.
5:e52
PMID: 17298186 -
Fukunaga et al.
(2007)
Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.
Br J Pharmacol.
151:870
PMID: 17502847 -
Xu et al.
(2007)
Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity.
Neuron.
53:399
PMID: 17270736 -
Nakamoto et al.
(2007)
Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors.
Proc Natl Acad Sci U S A.
104:15537
PMID: 17881561 -
Kuang et al.
(2006)
Ancestral reconstruction of the ligand-binding pocket of Family C G protein-coupled receptors.
J Neurosci.
103:14050
PMID: 16966606 -
El-Kouhen et al.
(2006)
Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist.
Br J Pharmacol.
149:761
PMID: 17016515 -
Ruangkittisakul et al.
(2006)
High sensitivity to neuromodulator-activated signaling pathways at physiological [K+] of confocally imaged respiratory center neurons in on-line-calibrated newborn rat brainstem slices.
J Neurosci.
26:11870
PMID: 17108160 -
Jung et al.
(2005)
Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors.
Proc Natl Acad Sci U S A.
68:1196
PMID: 16051747 -
Jacob et al.
(2005)
Signaling microdomains regulate inositol 1,4,5-trisphosphate-mediated intracellular calcium transients in cultured neurons.
Proc Natl Acad Sci U S A.
25:2853
PMID: 15772345 -
Wu et al.
(2004)
Group I metabotropic glutamate receptor activation produces a direct excitation of identified septohippocampal cholinergic neurons.
J Neurophysiol.
92:1216
PMID: 15044519 -
Cai et al.
(2004)
Activity-dependent expression of inositol 1,4,5-trisphosphate receptor type 1 in hippocampal neurons.
PLoS One.
279:23691
PMID: 15016804 -
Paladini et al.
(2003)
DA controls the firing pattern of DA neurons via a network feedback mechanism.
Sci Rep.
100:2866
PMID: 12604788
There are no citations that match your criteria.
Customer Reviews
5 out of 5
2 customer ratings
Showing 1-2 of 2 reviews
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Used in inhibitor cocktail
Species: RatAssay Type: In VitroCell Line/Tissue: Retinal rod bipolar cellsRetinal dissections were performed in HEPES-buffered extracellular solution containing glutamate inhibitor cocktail 100 umol/L
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No issues
Species: MouseAssay Type: Ex VivoCell Line/Tissue: C57BL/6Used this compound to induce Group I mGluR-dependent LTD in acute brain slices from the mouse hippocampus at a concentration of 50μM. Reliably induces LTD to 50-80% of baseline.Pay close attention to enantiomer. Some report that R,S-DHPG is not as effective at inducing LTD as S-DHPG alone, which is something I will anecdotally corroborate.
There are no reviews that match your criteria.
