(S)-3,5-DHPG

Citations are publications that use Bio-Techne products. Selected citations for (S)-3,5-DHPG include:

• Paul et al. (2019) Differential Regulation of Syngap1 Translation by FMRP Modulates eEF2 Mediated Response on NMDAR Activity. Front Mol Neurosci. 12:97
  PMID: 31143100
• Morel et al. (2018) JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory. J Neurosci. 38:3708
  PMID: 29540552
• Hellmer et al. (2018) A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina. Physiol Rep. 6:e13885
  PMID: 30338673
• Musella (2017) A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum. Sci Rep. 7(1):7363
  PMID: 28779174
• Hashimotodani et al. (2017) LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance. Neuron. 95:928
  PMID: 28817805
• Pallo et al. (2016) Mechanisms of tau and Aβ-induced excitotoxicity. Brain Res. 1634:119
  PMID: 26731336
• Tang and Alger (2015) Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome. J Neurosci. 35:3938
  PMID: 25740522
• Aguilar-Valles et al. (2015) Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2. Neuropharmacology. 35:11125
  PMID: 26245973
• Henderson et al. (2015) A Low Affinity GCaMP3 Variant (GCaMPer) for Imaging the Endoplasmic Reticulum Calcium Store. J Neurosci. 10:e0139273
  PMID: 26451944
• Ifrim et al. (2015) Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome. PLoS One. 35:7116
  PMID: 25948262
• Tang et al. (2015) Stimulation-evoked Ca²⁺ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. J Neurosci. 35:3016
  PMID: 25698739
• Zhao (2014) BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol. 111:1008
  PMID: 24335212
• Careaga et al. (2014) Group I metabotropic glutamate receptor mediated dynamic immune dysfunction in children with fragile X syndrome. J Neuroinflammation. 11:110
  PMID: 24942544
• Pollard et al. (2014) Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator. J Psychopharmacol. 28:935
  PMID: 25031220
• McQuail et al. (2013) Hippocampal Gαq/11 but not Gαo-coupled receptors are altered in aging. PLoS One. 70:63
  PMID: 23347951
• Kuribayashi et al. (2013) The role of metabotropic glutamate receptor 5 on the stromal cell-derived factor-1/CXCR4 system in oral cancer. J Biol Chem. 8:e80773
  PMID: 24236200
• Fairless et al. (2013) Membrane potential measurements of isolated neurons using a voltage-sensitive dye. PLoS One. 8:e58260
  PMID: 23516458
• Gregg et al. (2012) Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia. J Neurosci. 32:9457
  PMID: 22787031
• Bozdagi et al. (2012) Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice. J Neurosci. 7:e42422
  PMID: 22900020
• Peterfi et al. (2012) Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons. J Neurosci. 32:14448
  PMID: 23055515
• Taman and Ribeiro (2011) Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni. PLoS One. 6:e27119
  PMID: 22069494
• Zhao et al. (2011) Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus. J Neurosci. 31:725
  PMID: 21228181
• Pan et al. (2010) Ictal activity induced by group I metabotropic glutamate receptor activation and loss of afterhyperpolarizations. Neuropharmacology. 59:86
  PMID: 20385148
• Fu and Pol (2010) Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism. J Neurosci. 30:10205
  PMID: 20668204
• Filippov et al. (2010) The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons. Mol Pharmacol. 30:11068
  PMID: 20720114
• Westmark and Malter (2007) FMRP mediates mGluR5-dependent translation of amyloid precursor protein. PLoS Biol. 5:e52
  PMID: 17298186
• Fukunaga et al. (2007) Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices. Br J Pharmacol. 151:870
  PMID: 17502847
• Xu et al. (2007) Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity. Neuron. 53:399
  PMID: 17270736
• Nakamoto et al. (2007) Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors. Proc Natl Acad Sci U S A. 104:15537
  PMID: 17881561
• Kuang et al. (2006) Ancestral reconstruction of the ligand-binding pocket of Family C G protein-coupled receptors. J Neurosci. 103:14050
  PMID: 16966606
• El-Kouhen et al. (2006) Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br J Pharmacol. 149:761
  PMID: 17016515
• Ruangkittisakul et al. (2006) High sensitivity to neuromodulator-activated signaling pathways at physiological [K+] of confocally imaged respiratory center neurons in on-line-calibrated newborn rat brainstem slices. J Neurosci. 26:11870
  PMID: 17108160
• Jung et al. (2005) Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors. Proc Natl Acad Sci U S A. 68:1196
  PMID: 16051747
• Jacob et al. (2005) Signaling microdomains regulate inositol 1,4,5-trisphosphate-mediated intracellular calcium transients in cultured neurons. Proc Natl Acad Sci U S A. 25:2853
  PMID: 15772345
• Wu et al. (2004) Group I metabotropic glutamate receptor activation produces a direct excitation of identified septohippocampal cholinergic neurons. J Neurophysiol. 92:1216
  PMID: 15044519
• Cai et al. (2004) Activity-dependent expression of inositol 1,4,5-trisphosphate receptor type 1 in hippocampal neurons. PLoS One. 279:23691
  PMID: 15016804
• Paladini et al. (2003) DA controls the firing pattern of DA neurons via a network feedback mechanism. Sci Rep. 100:2866
  PMID: 12604788

There are no citations that match your criteria.

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• (2)

• Used in inhibitor cocktail

  Name: Anonymous
  Species: Rat
  Assay Type: In Vitro
  Cell Line/Tissue: Retinal rod bipolar cells
  Retinal dissections were performed in HEPES-buffered extracellular solution containing glutamate inhibitor cocktail 100 umol/L
  PMID: 30338673
  

• No issues

  Name: Talia James
  Species: Mouse
  Assay Type: Ex Vivo
  Cell Line/Tissue: C57BL/6
  Used this compound to induce Group I mGluR-dependent LTD in acute brain slices from the mouse hippocampus at a concentration of 50μM. Reliably induces LTD to 50-80% of baseline.
  Pay close attention to enantiomer. Some report that R,S-DHPG is not as effective at inducing LTD as S-DHPG alone, which is something I will anecdotally corroborate.
  

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