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Group I mGluR Agonists Small Molecule

Key Product Details

Description: Selective group I mGlu agonist; active enantiomer of 3,5-DHPG (Cat. No. 0342)
Chemical Name: (S)-3,5-Dihydroxyphenylglycine
Purity: ≥98% (HPLC)
Molecular Weight: 183.16

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Citations for (<em>S</em>)-3,5-DHPG (40)

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  • Used in inhibitor cocktail
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Retinal rod bipolar cells
    Retinal dissections were performed in HEPES-buffered extracellular solution containing glutamate inhibitor cocktail 100 umol/L
    (S)-3,5-DHPG Serum 0805
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    Name: Talia James
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: C57BL/6
    Used this compound to induce Group I mGluR-dependent LTD in acute brain slices from the mouse hippocampus at a concentration of 50μM. Reliably induces LTD to 50-80% of baseline.
    Pay close attention to enantiomer. Some report that R,S-DHPG is not as effective at inducing LTD as S-DHPG alone, which is something I will anecdotally corroborate.
    (S)-3,5-DHPG Serum 0805

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