VU 6028418 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 7658

Potent and selective M4 mAChR antagonist
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Key Product Details

Description

Potent and selective M4 mAChR antagonist

View all mAChR M4 Antagonists »

Product Description

VU 6028418 hydrochloride is a potent and selective M4 mAChR antagonist (IC50 = 4.1 nM and 57 nM for human and rat M4 respectively). VU 6028418 hydrochloride dose-dependently reduces the latency to withdraw and reverses cataleptic behavior in haloperidol-treated animals. Orally bioavailable.

Licensing Information

Sold under license from Vanderbilt University

Product Specifications

Molecular Weight

468.95

Formula

C23H27F3N4O.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(3aR,5s,6aS)-2-((Tetrahydro-2H-pyran-4-yl)methyl)-N-(6-(2,3,5-trifluorophenyl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine hydrochloride

InChI Key

IQDWZBQDZTVTLN-NESBVOEXSA-N

SMILES

[H][C@]12C[C@H](NC3=CC=C(C4=C(C(F)=CC(F)=C4)F)N=N3)C[C@]1(CN(C2)CC5CCOCC5)[H].Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.9 100
Ethanol 23.45 50

Preparing Stock Solutions for VU 6028418 hydrochloride

The following data is based on the product molecular weight 468.95

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.66 mL 21.32 mL
5 mM 0.43 mL 2.13 mL 4.26 mL
10 mM 0.21 mL 1.07 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for VU 6028418 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VU 6028418 hydrochloride

For research use only

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