Haloperidol hydrochloride

Name: Haloperidol hydrochloride
Brand: Tocris Bioscience
SKU: 0931
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 0931

Citations (9)

(1)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Dopamine antagonist; displays some D₂ selectivity
Chemical Name:	4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	412.33

View Full Technical Details for Haloperidol hydrochloride

Biological Activity for Haloperidol hydrochloride

Haloperidol hydrochloride is a dopamine antagonist with selectivity for D₂-like receptors (K_i values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D₂, D₃, D₄, D₁ and D₅ receptors respectively). Subtype-selective NMDA antagonist. Identified as targeting human host proteins that interact with SARS-CoV-2.

Technical Data for Haloperidol hydrochloride

M. Wt	412.33
Formula	C₂₁H₂₃ClFNO₂.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1511-16-6
PubChem ID	11495267
InChi Key	JMRYYMBDXNZQMH-UHFFFAOYSA-N
Smiles	Cl.OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Haloperidol hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	4.12	10 with gentle warming
	DMSO	10.31	25 with gentle warming

Preparing Stock Solutions for Haloperidol hydrochloride

The following data is based on the product molecular weight 412.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.70 mL	48.50 mL	97.01 mL
1.25 mM	1.94 mL	9.70 mL	19.40 mL
2.5 mM	0.97 mL	4.85 mL	9.70 mL
12.5 mM	0.19 mL	0.97 mL	1.94 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Haloperidol hydrochloride

References are publications that support the biological activity of the product.

Gordon A SARS-CoV-2 protein-protein interaction map reveals drug targets and drug repurposing. Nature 2020 PMID: 32353859
IIyin Subtype-selective inhibition of N-MthD.-aspartate receptors by halope. Mol.Pharmacol. 1996 PMID: 8967976
Lynch and Gallagher Inhibition of N-MthD.-aspartate receptors by haloperidol: development and pharmacological characterization in native and recombinant receptors. J.Pharmacol.Exp.Ther. 1996 PMID: 8858988
Seeman and Van Tol DA receptor pharmacology. TiPS 1994 PMID: 7940991
Beresford and Ward Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in psychosis. Drugs 1987 PMID: 3545764

Citations for Haloperidol hydrochloride (9)

Showing 1 - 9 of 9 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for Haloperidol hydrochloride include:

Joshi and Panicker (2019) Identifying the In Vivo Cellular Correlates of Antipsychotic Drugs. Eneuro. 5
PMID: 30713996
Canfrán-Duque et al. (2015) Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro. Biochem J. 10:e0141829
PMID: 26517556
Mishra et al. (2015) Theσ-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands. Brain Res. 466:263
PMID: 25510962
Czysz et al. (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. J Biomol Screen. 40:766
PMID: 25249058
Kim et al. (2012) Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun. 426:177
PMID: 22925888
Watson et al. (2012) The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood-brain barrier: evidence for involvement of breast cancer resistance protein. Neuropsychopharmacology. 1436:111
PMID: 22200378
Kurita et al. (2012) HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci. 15:1245
PMID: 22864611
Oliver and Davies (2009) Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk. Hum Mol Genet. 18:4576
PMID: 19729413
Balu et al. (2008) Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments. Brain Res. 1211:37
PMID: 18433734

There are no citations that match your criteria.

Showing 1 - 9 of 9 citations Showing All

Customer Reviews for Haloperidol hydrochloride (1)

5 out of 5

1 customer rating

5 stars

100%

4 stars

3 stars

2 stars

1 star

Customer Images

Showing 1 - 1 of 1 review Showing All

Filter By:

Antagonist of D2R

Name: Luiz Alexandre Magno

Species: Rat

Assay Type: In Vitro

Cell Line/Tissue: PC12 cells

I used haloperidol hydrochloride to block D2 dopamine receptors, which increases phosphorylation of the Akt protein (see the western blot image).

There are no reviews that match your criteria.

Showing 1 - 1 of 1 review Showing All

Product Documents for Haloperidol hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Haloperidol, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov