Verapamil hydrochloride

Name: Verapamil hydrochloride
Brand: Tocris Bioscience
SKU: 0654

Catalog # 0654

Citations (11)

COA / SDS

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Key Product Details

Description:	Ca_V1.x blocker
Chemical Name:	α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	491.07

View Full Technical Details for Verapamil hydrochloride

Biological Activity

Verapamil hydrochloride is an L-type calcium channel blocker. Vasodilator and adrenergic antagonist. Verapamil induces autophagy by modulating cellular metabolism. Verapamil has been identified as targeting human host proteins that interact with SARS-CoV-2.

Technical Data

M. Wt	491.07
Formula	C₂₇H₃₈N₂O₄.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	152-11-4
PubChem ID	62969
InChi Key	DOQPXTMNIUCOSY-UHFFFAOYSA-N
Smiles	Cl.COC1=CC=C(C=C1OC)C(CCCN(C)CCC1=CC(OC)=C(OC)C=C1)(C#N)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	24.55	50
	DMSO	24.55	50

Preparing Stock Solutions

The following data is based on the product molecular weight 491.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.07 mL	20.36 mL	40.73 mL
2.5 mM	0.81 mL	4.07 mL	8.15 mL
5 mM	0.41 mL	2.04 mL	4.07 mL
25 mM	0.08 mL	0.41 mL	0.81 mL

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References

References are publications that support the biological activity of the product.

Gordon A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 2020 PMID: 32353859
Kania Verapamil treatment induces cytoprotective autophagy by modulating cellular metabolism. FEBS J. 2017 PMID: 28342290
Fleming Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 2011 PMID: 21164513
Ustunes Effects of vera. on intimal thickening and vascular reactivity in the collared carotid artery of the rabbit. Br.J.Pharmacol. 1996 PMID: 8842432
Ishibashi Block of P-type Ca²⁺ channels in freshly dissociated rat cerebellar Purkinje neurons by dilt. and vera. Brain Res. 1995 PMID: 8574653
Lacinova Interaction of RO-40-5967 and vera. with the stably expressed α₁-subunit of the cardiac L-type calcium channel. J.Pharmacol.Exp.Ther. 1995 PMID: 7616442

Citations for Verapamil hydrochloride (11)

Showing 1 - 10 of 11 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Verapamil hydrochloride include:

Ferland et al. (2017) Chemerin-induced arterial contraction is Gi- and calcium-dependent. Vascul Pharmacol. 88:30
PMID: 27890480
Florea et al. (2017) Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma. Oncotarget. 8:22876
PMID: 28206967
McKeithan et al. (2017) An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol. 8:766
PMID: 29075196
Bragança et al. (2016) Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria. Front Pharmacol. 7:45
PMID: 27014060
Azab et al. (2015) Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane. FEMS Immunol Med Microbiol. 6
PMID: 26489864
Fransen et al. (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Cereb Cortex. 10:e0121634
PMID: 25803863
Chang et al. (2013) Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition. PLoS One. 34:1096
PMID: 23349021
Dhillon et al. (2013) Optimisation of embryonic and larval ECG measurement in zebrafish for quantifying the effect of QT prolonging drugs. PLoS One. 8:e60552
PMID: 23579446
Xia et al. (2011) Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicol Appl Pharmacol. 252:250
PMID: 21362439
Szikra et al. (2009) Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels. PLoS One. 4:e6723
PMID: 19696927
Wieland et al. (2006) Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels. Carcinogenesis. 47:296
PMID: 16831218

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