Veliparib dihydrochloride

Name: Veliparib dihydrochloride
Brand: Tocris Bioscience
SKU: 7026

Tocris Bioscience a Bio-Techne Brand

Catalog # 7026

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Key Product Details

Description:	High affinity PARP-1 and -2 inhibitor; orally bioavailable
Alternative Names:	ABT-888
Chemical Name:	2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	317.21

View Full Technical Details for Veliparib dihydrochloride

Biological Activity for Veliparib dihydrochloride

Veliparib dihydrochloride is a high affinity PARP-2 and PARP-1 inhibitor (K_i values are 2.9 and 5.2 nM, respectively). Inhibits repair of radiation-induced DNA damage and sensitizes lung cancer cells to radiation. Also increases autophagy and apoptosis in lung cancer cells. Enhances radiation-induced tumor growth delay in mice bearing lung tumor xenografts. Also chemosensitizer. Potentiates effects of temozolomide (Cat. No. 2706) in a mouse melanoma model. Orally bioavailable and brain penetrant.

Compound Libraries for Veliparib dihydrochloride

Veliparib dihydrochloride is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Veliparib dihydrochloride

M. Wt	317.21
Formula	C₁₃H₁₆N₄O.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	912445-05-7
PubChem ID	45480520
InChi Key	DSBSVDCHFMEYBX-FFXKMJQXSA-N
Smiles	C[C@]1(C2=NC3=CC=CC(C(N)=O)=C3N2)CCCN1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Veliparib dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	31.72	100
	water	31.72	100

Preparing Stock Solutions for Veliparib dihydrochloride

The following data is based on the product molecular weight 317.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.15 mL	15.76 mL	31.52 mL
5 mM	0.63 mL	3.15 mL	6.30 mL
10 mM	0.32 mL	1.58 mL	3.15 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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References for Veliparib dihydrochloride

References are publications that support the biological activity of the product.

Albert Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin.Cancer Res. 2007 PMID: 17505006
Donawho ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin.Cancer Res. 2007 PMID: 17473206

Citations for Veliparib dihydrochloride

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