Upadacitinib
Tocris Bioscience, part of Bio-Techne | Catalog # 7783
JAK1-selective inhibitor
Product Description
Upadacitinib is a potent and selective JAK1 inhibitor (IC50 = 47 nM). In a cellular assay, Upadacitinib shows selectivity for JAK1 over JAK2, JAK3 and TYK2 (IC50 values are 0.014 μM, 0.593 μM, 1860 μM and 2715 μM). In vivo, Upadacitinib suppresses paw swelling and bone destruction in a rat model of arthritis.Product Specifications
Molecular Weight
380.37
Formula
C17H19F3N6O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide
CAS Number
1310726-60-3
PubChem ID
58557659
InChI Key
WYQFJHHDOKWSHR-MNOVXSKESA-N
SMILES
C(C)[C@H]1[C@@](C=2N3C4=C(N=CC3=NC2)NC=C4)(CN(C(NCC(F)(F)F)=O)C1)[H]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.04 | 100 | |
| Ethanol | 19.02 | 50 |
Preparing Stock Solutions
for Upadacitinib
The following data is based on the product molecular weight 380.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.63 mL | 13.15 mL | 26.29 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.63 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Parmentier In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494). BMC Rheumatol. 2018 PMID: 30886973
Product Specific Notices for Upadacitinib
For research use only
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