Tubacin

Name: Tubacin
Brand: Tocris Bioscience
SKU: 3402

Tocris Bioscience, part of Bio-Techne | Catalog # 3402

Citations (14)

COA / SDS

HDAC6 inhibitor; inhibits α-tubulin deacetylation

Key Product Details

Description:	HDAC6 inhibitor; inhibits α-tubulin deacetylation
Chemical Name:	N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
Purity:	≥96% (HPLC)
Molecular Weight:	721.86

View Full Technical Details for Tubacin

Technical Data
Citations

Biological Activity for Tubacin

Tubacin is a selective inhibitor of HDAC6; inhibits the second deacetylase domain (DD2). Does not inhibit HDAC6 histone deacetylase activity; reversibly inhibits α-tubulin deacetylation. Increases α-tubulin acetylation levels with no effect on histone acetylation or cell cycle progression.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Tubacin is reviewed on the Chemical Probes website.

Technical Data for Tubacin

M. Wt	721.86
Formula	C₄₁H₄₃N₃O₇S
Storage	Store at -20°C
Purity	≥96% (HPLC)
CAS Number	1350555-93-9
PubChem ID	6675804
InChi Key	BHUZLJOUHMBZQY-YXQOSMAKSA-N
Smiles	OCC(C=C4)=CC=[C@@]4[C@@H]1C[C@H](CSC2=NC(C6=CC=CC=C6)=C(C5=CC=CC=C5)O2)O[C@H]([C@]3=CC=C(NC(CCCCCCC(NO)=O)=O)C=C3)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tubacin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.22	10

Preparing Stock Solutions for Tubacin

The following data is based on the product molecular weight 721.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.85 mL	69.27 mL	138.53 mL
0.5 mM	2.77 mL	13.85 mL	27.71 mL
1 mM	1.39 mL	6.93 mL	13.85 mL
5 mM	0.28 mL	1.39 mL	2.77 mL

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References for Tubacin

References are publications that support the biological activity of the product.

Haggarty Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc.Natl.Acad.Sci.USA 2003 PMID: 12677000
Jiang Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome. J.Neurosci. 2008 PMID: 19036992
Haggarty Multidimensional chemical genetic analysis of diversity-orientated synthesis-derived deacetylase inhibitors using cell-based assays. Chem.Biol. 2003 PMID: 12770821