Tubacin

Tocris Bioscience, part of Bio-Techne | Catalog # 3402

HDAC6 inhibitor; inhibits α-tubulin deacetylation
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Key Product Details

Description

HDAC6 inhibitor; inhibits α-tubulin deacetylation

View all Class II Histone Deacetylases Inhibitors »

Product Description

Tubacin is a selective inhibitor of HDAC6; inhibits the second deacetylase domain (DD2). Does not inhibit HDAC6 histone deacetylase activity; reversibly inhibits α-tubulin deacetylation. Increases α-tubulin acetylation levels with no effect on histone acetylation or cell cycle progression.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Tubacin is reviewed on the Chemical Probes website.

Product Specifications

Molecular Weight

721.86

Formula

C41H43N3O7S

Storage

Store at -20°C

Purity

≥96% (HPLC)

Chemical Name

N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide

CAS Number

1350555-93-9

PubChem ID

6675804

InChI Key

BHUZLJOUHMBZQY-YXQOSMAKSA-N

SMILES

OCC(C=C4)=CC=[C@@]4[C@@H]1C[C@H](CSC2=NC(C6=CC=CC=C6)=C(C5=CC=CC=C5)O2)O[C@H]([C@]3=CC=C(NC(CCCCCCC(NO)=O)=O)C=C3)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.22 10

Preparing Stock Solutions for Tubacin

The following data is based on the product molecular weight 721.86

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.85 mL 69.27 mL 138.53 mL
0.5 mM 2.77 mL 13.85 mL 27.71 mL
1 mM 1.39 mL 6.93 mL 13.85 mL
5 mM 0.28 mL 1.39 mL 2.77 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Tubacin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Tubacin

For research use only

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