TransMoDE 3 Biotin
Tocris Bioscience, part of Bio-Techne | Catalog # 8829
Biotinylated angiopep-2, induces internalization and degradation of streptavidin in brain cell lines
Key Product Details
Description
Biotinylated angiopep-2, induces internalization and degradation of streptavidin in brain cell lines
Product Description
TransMoDE 3 Biotin is a biotinylated peptide capable of inducing both the degradation of target protein via lysosomal proteolysis and their bidirectional transcytosis of streptavidin across the blood-brain barrier. TransMoDE 3 Biotin is derived from the peptide Angiopep-2 (Cat. No. 8828).Product Specifications
Molecular Weight
2611.88
Formula
C118H167N31O35S
Storage
Store at -20°C
Purity
≥95% (HPLC)
InChI Key
SDTCWCCIHKRCLZ-MKHRACNQSA-N
SMILES
O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCNC(C)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCCNC(CCCC[C@@H]5SC[C@@](N6)([H])[C@]5([H])NC6=O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC7=CC=C(C=C7)O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Howell Bifunctional Molecules That Induce Both Targeted Degradation and Transcytosis of Extracellular Proteins in Brain Cells. J Am Chem Soc 2024 PMID: 38855935
Product Specific Notices for TransMoDE 3 Biotin
For research use only
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