Angiopep-2

Name: Angiopep-2
Brand: Tocris Bioscience
SKU: 8828

Tocris Bioscience, part of Bio-Techne | Catalog # 8828

COA / SDS

Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB

Key Product Details

Description:	Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB
Purity:	≥95% (HPLC)
Molecular Weight:	2301.5

View Full Technical Details for Angiopep-2

Technical Data
Citations

Biological Activity for Angiopep-2

Angiopep-2 is a synthetic peptide able to specifically interact with low-density lipoprotein receptor-related protein 1 (LRP1) receptors present both on blood-brain barrier (BBB) and tumor cell membranes. Angiopep-2 binding to LRP1 facilitates receptor-mediated transcytosis of cargo across the BBB. Transcytosis-inducing molecular degraders of extracellular proteins (TransMoDEs), containing Angiopep-2 and modified to include a small-molecule ligand, induce target internalization that can cross the BBB in a variety of cell types.

Technical Data for Angiopep-2

M. Wt	2301.5
Formula	C₁₀₄H₁₄₉N₂₉O₃₁
Single Letter Sequence	TFFYGGSRGKRNNFKTEEY
Storage	Store at -20°C
Purity	≥95% (HPLC)
PubChem ID	134687501
InChi Key	RCVVJXYDPKEONQ-JVFWYHQTSA-N
Smiles	O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Angiopep-2

Solubility

Soluble to 1mg/ml in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Angiopep-2

References are publications that support the biological activity of the product.

Costagliola di Polidoro Revealing angiopep-2/LRP1 molecular interaction for optimal delivery to glioblastoma (GBM). Molecules 2022 PMID: 36235232
Howell Bifunctional molecules that induce both targeted degradation and transcytosis of extracellular proteins in brain cells. J.Am.Chem.Soc. 2024 PMID: 38855935