Key Product Details
Description: | Binds cereblon; also TNF-α synthesis inhibitor |
Chemical Name: | N-(2,6-dioxo-3-piperidinyl)phthalimide |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 258.23 |
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Citations for Thalidomide (12)
Citations are publications that use Bio-Techne products. Selected citations for Thalidomide include:
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Prete et al.
(2016)
Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.
J Biol Chem.
291:17209
PMID: 27325702 -
Helmy et al.
(2015)
Additive Renoprotection by pioglit. and fenofi. against Inflammatory, Oxidative and Apoptotic Manifestations of cisp. Nephrotoxicity: Modulation by PPARs.
PLoS One.
10:e0142303
PMID: 26536032 -
Kannappan et al.
(2010)
γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents.
J Biol Chem.
285:33520
PMID: 20720018 -
Gu et al.
(2010)
Intraperitoneal injection of Thal. attenuates bone cancer pain and decreases spinal tumor necrosis factor-α expression in a mouse model.
Mol Pain.
6:64
PMID: 20923560 -
Pandey et al.
(2010)
Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells.
Int J Cancer.
127:282
PMID: 19937797 -
Sandur et al.
(2010)
5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization.
Mol Cancer Res.
8:107
PMID: 20068065 -
Girgis et al.
(2010)
Effect of Thal. and arsenic trioxide on the release of tumor necrosis factor-α and vascular endothelial growth factor from the KG-1a human acute myelogenous leukemia cell line.
MBio.
1:663
PMID: 22966360 -
Sung et al.
(2009)
Curcumin circumvents chemoresistance in vitro and potentiates the effect of Thal. and borte. against human multiple myeloma in nude mice model.
Mol Cancer Ther.
8:959
PMID: 19372569 -
Ahn et al.
(2007)
Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.
Blood.
110:2286
PMID: 17609425 -
Pathak et al.
(2007)
Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.
Mol Cancer Res.
5:943
PMID: 17855663 -
Rocha et al.
(2006)
Relevance of tumour necrosis factor-alpha for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw.
Br J Pharmacol.
148:688
PMID: 16702985 -
Eter and Spitznas
(2002)
DMSO mimics inhibitory effect of Thal. on choriocapillary endothelial cell proliferation in culture.
Oncol Lett.
86:1303
PMID: 12386094
There are no citations that match your criteria.
⚠ WARNING: This product can expose you to chemicals including Thalidomide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov