Thalidomide
Tocris Bioscience, part of Bio-Techne | Catalog # 0652
Binds cereblon; also TNF-α synthesis inhibitor
Key Product Details
Description
Binds cereblon; also TNF-α synthesis inhibitor
Product Description
Thalidomide is a selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Anti-inflammatory; promotes T-cell activation. Predicted to reduce cytokine release in SARS-CoV-2 infection. Also binds cereblon, inhibiting ubiquitin ligase activity. Teratogenic and sedative-hypnotic. Promotes degradation of transcription factor SALL4.Product Specifications
Molecular Weight
258.23
Formula
C13H10N2O4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-(2,6-dioxo-3-piperidinyl)phthalimide
CAS Number
50-35-1
PubChem ID
5426
InChI Key
UEJJHQNACJXSKW-UHFFFAOYSA-N
SMILES
O=C1N(C2CCC(=O)NC2=O)C(=O)C2=C1C=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.46 | 25 |
Preparing Stock Solutions
for Thalidomide
The following data is based on the product molecular weight 258.23
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 15.49 mL | 77.45 mL | 154.90 mL |
| 1.25 mM | 3.10 mL | 15.49 mL | 30.98 mL |
| 2.5 mM | 1.55 mL | 7.75 mL | 15.49 mL |
| 12.5 mM | 0.31 mL | 1.55 mL | 3.10 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Li Network bioinformatics analysis provides insight into drug repurposing for COVID-2019. Med.Drug Discov. 2021 PMID: 33817623
- Ito Identification of a primary target of Thal. teratogenicity. Science 2010 PMID: 20223979
- Donovan Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome. Elife 2018 PMID: 30067223
- Sampaio Thal. selectively inhibits tumor necrosis factor α production by stimulated human monocytes. J.Exp.Med. 1991 PMID: 1997652
- Zhang Thal. influences growth and vasculogenic mimicry channel formation in melanoma. J.Exp.Clin.Cancer Res. 2008 PMID: 18983651
- Makonkawkeyoon Thal. inhibits the replication of human-immunodeficiency-virus type 1. Proc.Natl.Acad.Sci.U.S.A. 1993 PMID: 8327469
- Kanbayashi Thal., a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy. Neuroreport 1996 PMID: 8905685
- Boireau Thal. reduces MPTP-induced decrease in striatal DA levels in mice. Neurosci.Lett. 1997 PMID: 9364513
Product Specific Notices for Thalidomide
For research use only
⚠ WARNING: This product can expose you to chemicals including Thalidomide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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