Thalidomide, 5'-fluoro

Tocris Bioscience, part of Bio-Techne | Catalog # 7456

Fluoro functionalized Thalidomide; cereblon ligand for PROTACs
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Key Product Details

Description

Fluoro functionalized Thalidomide; cereblon ligand for PROTACs

View all Functionalized E3 Ligand Building Blocks »

Product Description

Thalidomide 5'- fluoro is a derivative of Thalidomide (Cat. No. 0652), commonly used as a precursor to PROTAC® Degraders that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with a fluoro functional handle at a position known not to significantly affect binding to cereblon, ready for conjugation to a linker/target protein ligand.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Require a different derivative? Get in touch.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications

Molecular Weight

276.22

Formula

C13H9FN2O4

Storage

Store at +4°C

Purity

≥95%

Chemical Name

2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-1H-isoindole-1,3(2H)-dione

CAS Number

835616-61-0

PubChem ID

70876201

InChI Key

MPQLCQKBYRSPNA-UHFFFAOYSA-N

SMILES

FC1=CC=C2C(N(C(C2=C1)=O)C3CCC(NC3=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for Thalidomide, 5'-fluoro

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Thalidomide, 5'-fluoro

For research use only

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