Tempol

Name: Tempol
Brand: Tocris Bioscience
SKU: 3082
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3082

(1)

Citations (51)

COA / SDS

Superoxide scavenger; antioxidant

Key Product Details

Description:	Superoxide scavenger; antioxidant
Chemical Name:	1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine
Purity:	≥98%
Molecular Weight:	172.24

View Full Technical Details for Tempol

Technical Data
Citations / Reviews (1)

Biological Activity for Tempol

Tempol is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Tempol reduces γ-radiation-induced damage in hematopoietic stem cells in vitro and in vivo.

Technical Data for Tempol

M. Wt	172.24
Formula	C₉H₁₈NO₂
Storage	Store at -20°C
Purity	≥98%
CAS Number	2226-96-2
PubChem ID	137994
InChi Key	UZFMOKQJFYMBGY-UHFFFAOYSA-N
Smiles	CC1(C)CC(O)CC(C)(C)N1[O]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tempol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	17.22	100
	ethanol	17.22	100

Preparing Stock Solutions for Tempol

The following data is based on the product molecular weight 172.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.81 mL	29.03 mL	58.06 mL
5 mM	1.16 mL	5.81 mL	11.61 mL
10 mM	0.58 mL	2.90 mL	5.81 mL
50 mM	0.12 mL	0.58 mL	1.16 mL

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Reconstitution Calculator

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References for Tempol

References are publications that support the biological activity of the product.

Ramachandran Prevention of γ-radiation induced cellular genotoxicity by tempol: Protection of hematopoietic system. Environ.Toxicol.Pharmacol. 2012 PMID: 22609778
Deng-Bryant Neuroprotective effect of tempol, a catalytic scavenger of peroxynitrite-derived free radicals, in a mouse traumatic brain injury model. J.Cereb.Blood Flow Metab. 2008 PMID: 18319733
Khattab TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion. EurJ.Pharmacol. 2006 PMID: 16973155
Francis and Sehgal The superoxide scavenger TEMPOL induces urok. receptor (uPAR) expression in human prostate cancer cells. Mol.Cancer 2006 PMID: 16756681