TCS JNK 6o

Name: TCS JNK 6o
Brand: Tocris Bioscience
SKU: 3222

Tocris Bioscience a Bio-Techne Brand

Catalog # 3222

Citations (3)

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Key Product Details

Description:	Selective JNK inhibitor
Chemical Name:	N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	356.38

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Biological Activity for TCS JNK 6o

TCS JNK 6o is an ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor (IC₅₀ values are 2, 4 and 52 nM for JNK1, JNK2 and JNK3 respectively). Displays > 1000 fold selectivity over other kinases, including ERK2 and p38. Inhibits c-Jun phosphorylation (EC₅₀ = 920 nM) and prevents collagen-induced platelet aggregation in vitro.

Technical Data for TCS JNK 6o

M. Wt	356.38
Formula	C₁₈H₂₀N₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	894804-07-0
PubChem ID	11624601
InChi Key	KQMPRSZTUSSXND-UHFFFAOYSA-N
Smiles	CCOC1=NC(NC(=O)CC2=CC(OC)=CC=C2OC)=CC(N)=C1C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TCS JNK 6o

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.64	100

Preparing Stock Solutions for TCS JNK 6o

The following data is based on the product molecular weight 356.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.81 mL	14.03 mL	28.06 mL
5 mM	0.56 mL	2.81 mL	5.61 mL
10 mM	0.28 mL	1.40 mL	2.81 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for TCS JNK 6o

References are publications that support the biological activity of the product.

Kauskot Involvement of the mirogen-activated protein kinase c-Jun NH₂-terminal kinase 1 in thrombus formation. J.Biol.Chem. 2007 PMID: 17785464
Szczepankiewicz Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J.Med.Chem. 2006 PMID: 16759099

Citations for TCS JNK 6o (3)

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Citations are publications that use Bio-Techne products. Selected citations for TCS JNK 6o include:

Xiao et al. (2019) Targeting JNK pathway promotes human hematopoietic stem cell expansion. Cell Discov. 5:2
PMID: 30622738
Souvannaseng et al. (2018) Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection. PLoS Pathog. 14:e1007418
PMID: 30496310
Yang et al. (2017) Establishment of mouse expanded potential stem cells. Nature. 550:393
PMID: 29019987

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Product Documents for TCS JNK 6o

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.