TC-G 1005
Tocris Bioscience, part of Bio-Techne | Catalog # 5129
Potent and selective GPBA receptor (TGR5) agonist
Key Product Details
Description
Potent and selective GPBA receptor (TGR5) agonist
Product Description
TC-G 1005 is a potent and selective GPBA agonist (EC50 values are 0.72 nM and 6.2 nM for hTGR5 and mTGR5, respectively). TC-G 1005 is selective for TGR5 over FXR (farnesoid X receptor). TC-G 1005 increases plasma GLP-1 levels and reduces blood glucose in mice. Orally bioavailable.Product Specifications
Molecular Weight
399.48
Formula
C25H25N3O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone
CAS Number
1415407-60-1
PubChem ID
71450251
InChI Key
JQULIQJSYPZQMA-UHFFFAOYSA-N
SMILES
CC1=CC(OC2=CC=NC=C2C(N3C(C=CC=C4)=C4N(C5CC5)CC3)=O)=C(C)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.95 | 100 | |
| Ethanol | 39.95 | 100 |
Preparing Stock Solutions
for TC-G 1005
The following data is based on the product molecular weight 399.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.50 mL | 12.52 mL | 25.03 mL |
| 5 mM | 0.50 mL | 2.50 mL | 5.01 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.50 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Urso Bile acids inhibit cholinergic constriction in proximal and peripheral airways from humans and rodents. Am.J.Physiol.Lung Cell.Mol.Physiol. 2020 PMID: 31800261
- Duan Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J.Med.Chem. 2012 PMID: 23148522
Product Specific Notices for TC-G 1005
For research use only
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