TC E3 5032

Name: TC E3 5032
Brand: Tocris Bioscience
SKU: 6628

Tocris Bioscience, part of Bio-Techne | Catalog # 6628

COA / SDS

Precursor to Pomalidomide-based PROTACs

Discontinued Product

6628 has been discontinued. View all Degrader Building Blocks products.

Key Product Details

Description:	Precursor to Pomalidomide-based PROTACs
Chemical Name:	2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	276.22

View Full Technical Details for TC E3 5032

Technical Data
Citations

Biological Activity for TC E3 5032

TC E3 5032 is a functionalized cereblon ligand for PROTAC^® research and development. Precursor to Pomalidomide (Cat.No. 6302) -based PROTACs. Incorporates a fluoro leaving group to allow conjugation to amine linker. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for TC E3 5032

M. Wt	276.22
Formula	C₁₃H₉FN₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	835616-60-9
PubChem ID	11859051
InChi Key	CRAUTELYXAAAPW-UHFFFAOYSA-N
Smiles	O=C(C1=C(C=CC=C1C2=O)F)N2C3CCC(NC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for TC E3 5032

References are publications that support the biological activity of the product.

Remillard Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 2017 PMID: 28418626