Thalidomide-4-hydroxyacetate

Name: Thalidomide-4-hydroxyacetate
Brand: Tocris Bioscience
SKU: 6466

Tocris Bioscience, part of Bio-Techne | Catalog # 6466

COA / SDS

Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs

Key Product Details

Description:	Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs
Chemical Name:	2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	332.26

View Full Technical Details for Thalidomide-4-hydroxyacetate

Technical Data
Citations

Biological Activity for Thalidomide-4-hydroxyacetate

Thalidomide-4-hydroxyacetate is a derivative of Thalidomide (Cat.No. 0652), commonly used as a precursor to PROTAC^® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with a carboxylic acid functional handle at a position known not to significantly affect binding to cereblon, for ready conjugation to a linker/target protein ligand.

Thalidomide-4-hydroxyacetate has been recently renamed. The previous name for this product was TC E3 5031.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Require a different derivative? Get in touch.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Thalidomide-4-hydroxyacetate

M. Wt	332.26
Formula	C₁₅H₁₂N₂O₇
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1061605-21-7
PubChem ID	25015436
InChi Key	ZVWIXIGBWIEDFO-UHFFFAOYSA-N
Smiles	O=C(N1C(CC2)C(NC2=O)=O)C3=C(C1=O)C(OCC(O)=O)=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Thalidomide-4-hydroxyacetate

References are publications that support the biological activity of the product.

Lohbeck and Miller Practical synthesis of a phthalimide-based cereblon ligand to enable PROTAC development. Bioorg.Med.Chem.Lett. 2016 PMID: 27687673