Tasquinimod
Tocris Bioscience, part of Bio-Techne | Catalog # 7051
High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic
Key Product Details
Description
High affinity HDAC4 negative allosteric modulator; also binds S100A9; antiangiogenic
Product Description
Tasquinimod is a high affinity negative allosteric modulator of HDAC4 (Kd = 10 - 30 nM). Binds the regulatory Zn2+ binding domain of HDAC4. Suppresses hypoxia-induced decrease in histone acetylation in human prostate cancer cells in vitro. Also binds S100A9. Antiangiogenic. Inhibits endothelial sprouting in vitro and growth of prostate tumor xenografts in nude mice. Orally bioavailable.Product Specifications
Molecular Weight
406.36
Formula
C20H17F3N2O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-3-quinolinecarboxamide
CAS Number
254964-60-8
PubChem ID
54682876
InChI Key
ONDYALNGTUAJDX-UHFFFAOYSA-N
SMILES
COC1=C2C(O)=C(C(=O)N(C)C3=CC=C(C=C3)C(F)(F)F)C(=O)N(C)C2=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.64 | 100 | |
| Ethanol | 8.13 | 20 |
Preparing Stock Solutions
for Tasquinimod
The following data is based on the product molecular weight 406.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.46 mL | 12.30 mL | 24.61 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.92 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Isaacs Anti-cancer potency of Tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment. Oncotarget 2014 PMID: 25193858
- Isaacs Tasquinimod is an allosteric modulator of HDAC4 survival signaling within the compromised cancer microenvironment. Cancer Res. 2013 PMID: 23149916
Product Specific Notices for Tasquinimod
For research use only
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