StemRegenin 1

Name: StemRegenin 1
Brand: Tocris Bioscience
SKU: 7086

Tocris Bioscience, part of Bio-Techne | Catalog # 7086

Citations (2)

COA / SDS

Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment

Key Product Details

Description:	Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment
Chemical Name:	4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]phenol
Purity:	≥98% (HPLC)
Molecular Weight:	429.54

View Full Technical Details for StemRegenin 1

Technical Data
Citations

Biological Activity for StemRegenin 1

StemReginin 1 is an aryl hydrocarbon receptor (AHR) antagonist (IC₅₀ = 127 nM). StemReginin 1 exhibits no inhibitory activity against a panel of 61 kinases and preferentially inhibits human AHR. StemReginin 1 promotes the expansion of CD34+ cells ex vivo. In hematopoietic stem cell (HSC) culture, the compound induces a 50-fold increase in CD34-expressing cells, and HSCs cultured with StemReginin 1 show increased engraftment in mice. Combination of StemReginin 1 with DMOG (Cat. No. 4408) increases the proportion of primitive HSCs and improves long-term engraftment. The product also promotes expansion of human promyelocytic leukemia cell line NB4.

Technical Data for StemRegenin 1

M. Wt	429.54
Formula	C₂₄H₂₃N₅OS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1227633-49-9
PubChem ID	46199207
InChi Key	BGFHMYJZJZLMHW-UHFFFAOYSA-N
Smiles	CC(N1C=NC2=C(N=C(C3=CSC4=CC=CC=C34)N=C12)NCCC5=CC=C(C=C5)O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for StemRegenin 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.95	100

Preparing Stock Solutions for StemRegenin 1

The following data is based on the product molecular weight 429.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.64 mL	23.28 mL
5 mM	0.47 mL	2.33 mL	4.66 mL
10 mM	0.23 mL	1.16 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for StemRegenin 1

References are publications that support the biological activity of the product.

Koide Aryl hydrocarbon receptor antagonist StemRegenin 1 promotes the expansion of human promyelocytic leukemia cell line, NB4. Anticancer Res. 2016 PMID: 27354634
Genovese Targeted genome editing in human repopulating haematopoietic stem cells. Nature 2014 PMID: 24870228
Boitano Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 2010 PMID: 20688981
Jackson Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion. Stem Cell Res. 2017 PMID: 28445828