SSR 146977 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3297
Potent and selective NK3 antagonist
Key Product Details
Description
Potent and selective NK3 antagonist
Product Description
SSR 146977 hydrochloride is a potent and selective NK3 receptor antagonist (Ki values are 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor respectively). Also inhibits senktide-induced inositol monophosphate formation and intracellular calcium mobilization (IC50 = 10 nM).Product Specifications
Molecular Weight
658.11
Formula
C35H42Cl2N4O2.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N1-[1-3-[(3R)-1-Benzoyl-3-(3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-piperidinyl]-N,N-dimethylurea hydrochloride
CAS Number
264618-38-4
PubChem ID
90488827
InChI Key
HYPKKQPFHSNZBY-GXUZKUJRSA-N
SMILES
O=C(N(C)C)NC1(C4=CC=CC=C4)CCN(CCC[C@]3(CN(C(C5=CC=CC=C5)=O)CCC3)[C@]2=CC=C(Cl)C(Cl)=C2)CC1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 65.81 | 100 | |
| Ethanol | 65.81 | 100 |
Preparing Stock Solutions
for SSR 146977 hydrochloride
The following data is based on the product molecular weight 658.11
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.52 mL | 7.60 mL | 15.20 mL |
| 5 mM | 0.30 mL | 1.52 mL | 3.04 mL |
| 10 mM | 0.15 mL | 0.76 mL | 1.52 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.30 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Emonds-Alt Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist. Can.J.Physiol.Pharmacol. 2002 PMID: 12056557
Product Specific Notices for SSR 146977 hydrochloride
For research use only
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