SR 8278
Tocris Bioscience, part of Bio-Techne | Catalog # 4463
Rev-Erbα antagonist
Product Description
SR 8278 is a Rev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM). Blocks activity of Rev-Erbα agonist GSK 4112 (Cat. No. 3663) in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells.Product Specifications
Molecular Weight
361.48
Formula
C18H19NO3S2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
CAS Number
1254944-66-5
PubChem ID
53393127
InChI Key
UIEBLUZPSFAFOC-UHFFFAOYSA-N
SMILES
CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C1=CC=C(SC)S1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.15 | 100 | |
| Ethanol | 18.07 | 50 |
Preparing Stock Solutions
for SR 8278
The following data is based on the product molecular weight 361.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.83 mL | 27.66 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.53 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kojetin Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem. Biol. 2011 PMID: 21043485
Product Specific Notices for SR 8278
For research use only
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