GSK 4112
Tocris Bioscience, part of Bio-Techne | Catalog # 3663
Selective Rev-Erbα agonist
Key Product Details
Description
Selective Rev-Erbα agonist
Alternative Names
SR 6452
Product Description
GSK 4112 is a selective Rev-Erbα agonist (EC50 = 250 nM). Enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Induces phase shifts in the circadian clock.Product Specifications
Molecular Weight
396.89
Formula
C18H21ClN2O4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
CAS Number
1216744-19-2
PubChem ID
50905018
InChI Key
WYSLOKHVFKLWOU-UHFFFAOYSA-N
SMILES
CC(C)(C)OC(CN(CC2=CC=C(Cl)C=C2)CC1=CC=C([N+]([O-])=O)S1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.92 | 25 |
Preparing Stock Solutions
for GSK 4112
The following data is based on the product molecular weight 396.89
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 10.08 mL | 50.39 mL | 100.78 mL |
| 1.25 mM | 2.02 mL | 10.08 mL | 20.16 mL |
| 2.5 mM | 1.01 mL | 5.04 mL | 10.08 mL |
| 12.5 mM | 0.20 mL | 1.01 mL | 2.02 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kojetin Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem.Biol. 2011 PMID: 21043485
- Meng Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner. J.Cell Science 2008 PMID: 18946026
Product Specific Notices for GSK 4112
For research use only
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