SR 48692
Tocris Bioscience, part of Bio-Techne | Catalog # 3721
Selective non-peptide NTS1 antagonist
Key Product Details
Description
Selective non-peptide NTS1 antagonist
Product Description
SR 48692 is a neurotensin antagonist; selective for NTS1 over NTS2 (apparent affinity, Ke, is 36 nM for NTS1). Competitively inhibits binding of [125I]-neurotensin to HT29 and N1E115 cell membranes (IC50 values are 15.3 and 20.4 nM respectively). Orally bioavailable.Product Specifications
Molecular Weight
587.07
Formula
C32H31ClN4O5
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-[[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid
CAS Number
146362-70-1
PubChem ID
119192
InChI Key
DYLJVOXRWLXDIG-UHFFFAOYSA-N
SMILES
O=C(NC5(C(O)=O)C4CC(CC5C6)CC6C4)C2=NN(C(C3=C(OC)C=CC=C3OC)=C2)C1=C(C=CC(Cl)=C7)C7=NC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.74 | 20 |
Preparing Stock Solutions
for SR 48692
The following data is based on the product molecular weight 587.07
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 8.52 mL | 42.58 mL | 85.17 mL |
| 1 mM | 1.70 mL | 8.52 mL | 17.03 mL |
| 2 mM | 0.85 mL | 4.26 mL | 8.52 mL |
| 10 mM | 0.17 mL | 0.85 mL | 1.70 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Oury-Donat Characterization of the effect of SR48692 on inositol monophosphate, cyclic GMP and cyclic AMP responses linked to neurotensin receptor activation in neuronal and non-neuronal cells. Br.J.Pharmacol. 1995 PMID: 8528577
- Thomas The identification of nonpeptide neurotensin receptor partial agonists from the potent antagonist SR48692 using a calcium mobilization assay. Bioorg.Med.Chem.Lett. 2009 PMID: 19195889
- Gully Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor. Proc.Natl.Acad.Sci.USA 1993 PMID: 8380498
Product Specific Notices for SR 48692
For research use only
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