SNDX-5613 New
Tocris Bioscience, part of Bio-Techne | Catalog # 8907
Menin-MLL interaction inhibitor
Key Product Details
Description
Menin-MLL interaction inhibitor
Alternative Names
Revumenib
Product Description
SNDX-5613 is a potent inhibitor of menin-MLL1 protein-protein interaction (Ki = 0.149 nM; IC50 = 10-20 nM). Orally bioavailable.Product Specifications
Molecular Weight
630.82
Formula
C32H47FN6O4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-Ethyl-2-[[4-[7-[[trans-4-[(ethylsulfonyl)amino]cyclohexyl]methyl]-2,7-diazaspiro[3.5]non-2-yl]-5-pyrimidinyl]oxy]-5-fluoro-N-(1-methylethyl)benzamide
CAS Number
2169919-21-3
PubChem ID
132212657
InChI Key
FRVSRBKUQZKTOW-YOCNBXQISA-N
SMILES
CC(N(C(C1=CC(F)=CC=C1OC2=C(N=CN=C2)N3CC4(C3)CCN(CC4)C[C@@H]5CC[C@H](CC5)NS(CC)(=O)=O)=O)CC)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.54 | 50 | |
| Ethanol | 12.62 | 20 |
Preparing Stock Solutions
for SNDX-5613
The following data is based on the product molecular weight 630.82
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.17 mL | 15.85 mL | 31.70 mL |
| 2.5 mM | 0.63 mL | 3.17 mL | 6.34 mL |
| 5 mM | 0.32 mL | 1.59 mL | 3.17 mL |
| 25 mM | 0.06 mL | 0.32 mL | 0.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Issa The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia. Nature 2023 PMID: 36922593
- Fiskus Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1. Blood Cancer J. 2023 PMID: 37055414
Product Specific Notices for SNDX-5613
For research use only
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