SMER 3
Tocris Bioscience, part of Bio-Techne | Catalog # 4375
Selective inhibitor of E3 ubiquitin ligase
Key Product Details
Description
Selective inhibitor of E3 ubiquitin ligase
Product Description
SMER 3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin (Cat. No. 1292).Product Specifications
Molecular Weight
224.18
Formula
C11H4N4O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
CAS Number
67200-34-4
PubChem ID
568763
InChI Key
SFSSAKVWCKFRHE-UHFFFAOYSA-N
SMILES
O=C4C2=NC1=NON=C1N=C2C3=CC=CC=C34
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.81 | 75 |
Preparing Stock Solutions
for SMER 3
The following data is based on the product molecular weight 224.18
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 5.95 mL | 29.74 mL | 59.48 mL |
| 3.75 mM | 1.19 mL | 5.95 mL | 11.90 mL |
| 7.5 mM | 0.59 mL | 2.97 mL | 5.95 mL |
| 37.5 mM | 0.12 mL | 0.59 mL | 1.19 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Aghajanyy Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor. Nat.Biotechnol. 2010 PMID: 20581845
Product Specific Notices for SMER 3
For research use only
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