SM 16

Name: SM 16
Brand: Tocris Bioscience
SKU: 6245

Tocris Bioscience, part of Bio-Techne | Catalog # 6245

COA / SDS

Potent TGF-βRI inhibitor; orally bioavailable

Key Product Details

Description:	Potent TGF-βRI inhibitor; orally bioavailable
Chemical Name:	4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	430.5

View Full Technical Details for SM 16

Technical Data
Citations

Biological Activity for SM 16

SM 16 is a potent TGF-β receptor type 1 (TGF-βRI) inhibitor (IC₅₀ = 64 nM in luciferase assay). Selective for TGF-βRI over other ALK family members. Decreases Smad phosphorylation and inhibits tumor growth in a mouse xenograft model. Attenuates increased TGF-β signaling in retinal vessels of diabetic rats. Also prevents intimal thickening and vascular remodeling in rat carotid balloon injury model. Orally bioavailable.

Compound Libraries for SM 16

SM 16 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for SM 16

M. Wt	430.5
Formula	C₂₅H₂₆N₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	614749-78-9
PubChem ID	10387982
InChi Key	JUHTXZGCTPDXRU-UHFFFAOYSA-N
Smiles	CC1=NC(C2=C(C3=CC=C4OCOC4=C3)NC(C56CCC(CC6)(C(N)=O)CC5)=N2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SM 16

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.05	100

Preparing Stock Solutions for SM 16

The following data is based on the product molecular weight 430.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.61 mL	23.23 mL
5 mM	0.46 mL	2.32 mL	4.65 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for SM 16

References are publications that support the biological activity of the product.

Fu SM16, an orally active TGF-β type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler.Thromb.Vasc.Biol. 2008 PMID: 18202322
Dagher The increased transforming growth factor-β signaling induced by diabetes protects retinal vessels. Am.J.Pathol. 2017 PMID: 28162229
Suzuki A novel small-molecule inhibitor of transforming growth factor β type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. Cancer Res. 2007 PMID: 17332368