SJF 1521

Name: SJF 1521
Brand: Tocris Bioscience
SKU: 7261

Tocris Bioscience, part of Bio-Techne | Catalog # 7261

Citations (1)

COA / SDS

Selective EGFR PROTAC® Degrader

Key Product Details

Description:	Selective EGFR PROTAC^® Degrader
Chemical Name:	(2S,4R)-1-((S)-2-(tert-Butyl)-14-(4-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	1074.66

View Full Technical Details for SJF 1521

Technical Data
Citations

Biological Activity for SJF 1521

SJF 1521 is a selective EGFR PROTAC^® Degrader. SJF 1521 comprises the EGFR inhibitor lapatinib (Cat. No. 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Exhibits selectivity for EGFR, including mutant forms, over HER2. Induces degradation of EGFR in OVCAR8 cells.

EGFR antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF231

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for SJF 1521

M. Wt	1074.66
Formula	C₅₇H₆₁ClFN₇O₉S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2230821-40-4
PubChem ID	135157094
InChi Key	XZNORRXEBCTXPB-KHBXAZQSSA-N
Smiles	CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCOC4=CC=C(C5=CC6=C(N=CN=C6NC7=CC(Cl)=C(C=C7)OCC8=CC(F)=CC=C8)C=C5)C=C4)=O)=O)O)=O)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SJF 1521

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	107.47	100

Preparing Stock Solutions for SJF 1521

The following data is based on the product molecular weight 1074.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.93 mL	4.65 mL	9.31 mL
5 mM	0.19 mL	0.93 mL	1.86 mL
10 mM	0.09 mL	0.47 mL	0.93 mL
50 mM	0.02 mL	0.09 mL	0.19 mL

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References for SJF 1521

References are publications that support the biological activity of the product.

Burslem The advantages of targeted protein degradation over inhibition: an RTK case study. Cell Chem.Biol. 2018 PMID: 29129716